STRINGSTRING
phnN phnN prs prs hisG hisG purF purF hisZ hisZ pyrE pyrE PSEEN2877 PSEEN2877 phnC phnC PSEEN0992 PSEEN0992 PSEEN0994 PSEEN0994 PSEEN0995 PSEEN0995
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
phnNATP-binding protein PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (207 aa)    
Predicted Functional Partners:
prs
Ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
     
  0.900
hisG
ATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
     
  0.800
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
  0.800
hisZ
Putative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
     
  0.800
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
     
  0.800
PSEEN2877
Putative Phosphonate-binding periplasmic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
 
  
 0.693
phnC
Putative phosphonate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
 
  
 0.670
PSEEN0992
Putative phosphonate ABC transporter, periplasmic phosphonate-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
 
  
 0.576
PSEEN0994
Putative phosphonate ABC transporter, permease protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
 
  
 0.518
PSEEN0995
Putative phosphonate ABC transporter, permease protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
 
  
 0.485
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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