node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN1997 | dnaN | PSEEN1997 | PSEEN0002 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.931 |
PSEEN1997 | polA | PSEEN1997 | PSEEN0076 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.972 |
PSEEN1997 | radA | PSEEN1997 | PSEEN4770 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.645 |
PSEEN1997 | recA | PSEEN1997 | PSEEN4128 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.942 |
PSEEN1997 | recX | PSEEN1997 | PSEEN4127 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Regulatory protein, inhibitor of RecA recombinase and coprotease activities; Modulates RecA activity; Belongs to the RecX family. | 0.445 |
PSEEN1997 | sbcD | PSEEN1997 | PSEEN1722 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Exonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.948 |
PSEEN3390 | polA | PSEEN3390 | PSEEN0076 | Putative transcriptional regulator, Cro/CI family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.432 |
PSEEN3390 | recA | PSEEN3390 | PSEEN4128 | Putative transcriptional regulator, Cro/CI family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.876 |
PSEEN3390 | recX | PSEEN3390 | PSEEN4127 | Putative transcriptional regulator, Cro/CI family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Regulatory protein, inhibitor of RecA recombinase and coprotease activities; Modulates RecA activity; Belongs to the RecX family. | 0.404 |
dnaN | PSEEN1997 | PSEEN0002 | PSEEN1997 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.931 |
dnaN | polA | PSEEN0002 | PSEEN0076 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.990 |
dnaN | recA | PSEEN0002 | PSEEN4128 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.831 |
dnaN | sbcD | PSEEN0002 | PSEEN1722 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Exonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.516 |
lexA | polA | PSEEN3721 | PSEEN0076 | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.499 |
lexA | recA | PSEEN3721 | PSEEN4128 | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.899 |
lexA | recX | PSEEN3721 | PSEEN4127 | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Regulatory protein, inhibitor of RecA recombinase and coprotease activities; Modulates RecA activity; Belongs to the RecX family. | 0.550 |
lexA-2 | polA | PSEEN2412 | PSEEN0076 | Putative LexA repressor 2; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.499 |
lexA-2 | recA | PSEEN2412 | PSEEN4128 | Putative LexA repressor 2; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.897 |
lexA-2 | recX | PSEEN2412 | PSEEN4127 | Putative LexA repressor 2; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Regulatory protein, inhibitor of RecA recombinase and coprotease activities; Modulates RecA activity; Belongs to the RecX family. | 0.538 |
polA | PSEEN1997 | PSEEN0076 | PSEEN1997 | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.972 |