node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN0889 | apt | PSEEN0889 | PSEEN1791 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.930 |
PSEEN0889 | gmk | PSEEN0889 | PSEEN5441 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.948 |
PSEEN0889 | guaA | PSEEN0889 | PSEEN4392 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.955 |
PSEEN0889 | guaB | PSEEN0889 | PSEEN4393 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
PSEEN0889 | purL | PSEEN0889 | PSEEN4386 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.532 |
PSEEN0889 | rdgB | PSEEN0889 | PSEEN0312 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.911 |
PSEEN0889 | surE | PSEEN0889 | PSEEN4192 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.901 |
PSEEN0889 | xpt | PSEEN0889 | PSEEN5411 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.927 |
PSEEN2521 | guaA | PSEEN2521 | PSEEN4392 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.994 |
PSEEN2521 | purL | PSEEN2521 | PSEEN4386 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.731 |
PSEEN2521 | pyrG | PSEEN2521 | PSEEN4202 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.626 |
PSEEN2521 | rdgB | PSEEN2521 | PSEEN0312 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.486 |
apt | PSEEN0889 | PSEEN1791 | PSEEN0889 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.930 |
apt | gmk | PSEEN1791 | PSEEN5441 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.951 |
apt | guaA | PSEEN1791 | PSEEN4392 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.988 |
apt | purL | PSEEN1791 | PSEEN4386 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.767 |
apt | pyrG | PSEEN1791 | PSEEN4202 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.483 |
apt | surE | PSEEN1791 | PSEEN4192 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.911 |
apt | xpt | PSEEN1791 | PSEEN5411 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.909 |
gmk | PSEEN0889 | PSEEN5441 | PSEEN0889 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.948 |