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leuA leuA ilvD ilvD leuC leuC leuD leuD ilvE ilvE ilvH ilvH PSEEN0664 PSEEN0664 PSEEN2543 PSEEN2543 pcaF-2 pcaF-2 PSEEN3197 PSEEN3197 fadAx fadAx
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (557 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
 
 
 0.983
leuC
3-isopropylmalate dehydratase (isomerase), large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.982
leuD
3-isopropylmalate isomerase (dehydratase), small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.979
ilvE
Branched-chain amino acid aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.976
ilvH
Acetolactate synthase isozyme III, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.933
PSEEN0664
Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.924
PSEEN2543
Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.924
pcaF-2
Beta-ketoadipyl CoA thiolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.924
PSEEN3197
Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.924
fadAx
acetyl-CoA acetyltransferase with thiolase domain FadAx; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.924
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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