STRINGSTRING
glyA-2 glyA-2 soxA soxA gcvP-2 gcvP-2 gcvP-1 gcvP-1 purH purH soxB soxB soxD soxD gcvT-2 gcvT-2 gcvT-1 gcvT-1 folD folD purN purN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)    
Predicted Functional Partners:
soxA
Sarcosine oxidase (alpha subunit) oxidoreductase protein; Function of strongly homologous gene; enzyme; Belongs to the GcvT family.
  
 0.988
gcvP-2
Glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.986
gcvP-1
Glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.986
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.976
soxB
Sarcosine oxidase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.976
soxD
Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme.
  
 
  0.972
gcvT-2
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme.
 
 0.967
gcvT-1
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; The glycine cleavage system catalyzes the degradation of glycine.
 
 0.967
folD
Bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 0.960
purN
Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.952
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
Server load: low (10%) [HD]