STRINGSTRING
TK90_2465 TK90_2465 thiG thiG TK90_0336 TK90_0336 TK90_2189 TK90_2189 thiE thiE thiC thiC TK90_0393 TK90_0393 trmB trmB TK90_2579 TK90_2579 tilS tilS TK90_0244 TK90_0244
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
TK90_2465TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: psp:PSPPH_4775 sulfur carrier protein ThiS. (68 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.999
TK90_0336
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pae:PA4663 molybdopterin biosynthesis protein MoeB.
  
 
 0.939
TK90_2189
PFAM: thiamine monophosphate synthase; NUDIX hydrolase; KEGG: avn:Avin_13370 MutT/NUDIX family protein; Belongs to the Nudix hydrolase family.
 
  
 0.870
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.861
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.837
TK90_0393
KEGG: cvi:CV_0151 hydroxymethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
  
    0.829
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
       0.741
TK90_2579
PFAM: PP-loop domain protein; KEGG: hna:Hneap_2075 PP-loop domain protein; Belongs to the TtcA family.
  
   0.630
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
   
   0.623
TK90_0244
D-amino-acid dehydrogenase; PFAM: FAD dependent oxidoreductase; KEGG: aeh:Mlg_0415 D-amino acid dehydrogenase small subunit.
 
  
 0.478
Your Current Organism:
Thioalkalivibrio sp. K90mix
NCBI taxonomy Id: 396595
Other names: T. sp. K90mix
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