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pyrE pyrE pyrD pyrD pyrF pyrF carB carB pyrB pyrB AAO58469.1 AAO58469.1 carA carA prsA prsA pyrR pyrR AAO57789.1 AAO57789.1 AAO58666.1 AAO58666.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.994
pyrF
Orotidine 5-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.993
carB
Carbamoyl-phosphate synthase, large subunit; See PMID:20190049 for expression data.
  
 
 0.945
pyrB
Aspartate carbamoyltransferase; See PMID:20190049 for expression data; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.940
AAO58469.1
Dihydroorotase, multifunctional complex type; See PMID:20190049 for expression data.
  
  
 0.940
carA
Carbamoyl-phosphate synthase, small subunit; See PMID:20190049 for expression data; Belongs to the CarA family.
  
  
 0.925
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.883
pyrR
Pyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
  
  
 0.853
AAO57789.1
Oxidoreductase, iron-sulfur-binding protein; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00970.
  
  
 0.842
AAO58666.1
Oxidoreductase, iron-sulfur-binding protein; See PMID:20190049 for expression data.
  
  
 0.842
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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