node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO55936.1 | folA | PSPTO_2427 | PSPTO_0437 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.917 |
AAO55936.1 | folD-1 | PSPTO_2427 | PSPTO_2453 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.957 |
AAO55936.1 | folD-2 | PSPTO_2427 | PSPTO_3733 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
AAO55936.1 | glyA-1 | PSPTO_2427 | PSPTO_0461 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
AAO55936.1 | glyA-2 | PSPTO_2427 | PSPTO_4632 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
AAO55936.1 | metH | PSPTO_2427 | PSPTO_2732 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.939 |
AAO55936.1 | purN | PSPTO_2427 | PSPTO_1699 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.947 |
AAO55936.1 | purT | PSPTO_2427 | PSPTO_1468 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.908 |
AAO55936.1 | purU-1 | PSPTO_2427 | PSPTO_0456 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.910 |
AAO55936.1 | purU-3 | PSPTO_2427 | PSPTO_4314 | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.911 |
folA | AAO55936.1 | PSPTO_0437 | PSPTO_2427 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | 0.917 |
folA | glyA-1 | PSPTO_0437 | PSPTO_0461 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.917 |
folA | glyA-2 | PSPTO_0437 | PSPTO_4632 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.917 |
folA | metH | PSPTO_0437 | PSPTO_2732 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.939 |
folA | purN | PSPTO_0437 | PSPTO_1699 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.937 |
folA | purT | PSPTO_0437 | PSPTO_1468 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
folA | purU-1 | PSPTO_0437 | PSPTO_0456 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.909 |
folA | purU-3 | PSPTO_0437 | PSPTO_4314 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.909 |
folD-1 | AAO55936.1 | PSPTO_2453 | PSPTO_2427 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase, putative; Similar to GB:Z35428, PID:515905, and SP:P53522; identified by sequence similarity; putative. | 0.957 |
folD-1 | folD-2 | PSPTO_2453 | PSPTO_3733 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.905 |