node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO53964.1 | iscS-1 | PSPTO_0420 | PSPTO_0272 | Rhodanese-like domain protein; See PMID:20190049 for expression data; similar to GP:2661707; identified by sequence similarity; putative. | Cysteine desulfurase; Similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.914 |
AAO53964.1 | iscS-2 | PSPTO_0420 | PSPTO_1423 | Rhodanese-like domain protein; See PMID:20190049 for expression data; similar to GP:2661707; identified by sequence similarity; putative. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.914 |
AAO53964.1 | iscS-3 | PSPTO_0420 | PSPTO_3438 | Rhodanese-like domain protein; See PMID:20190049 for expression data; similar to GP:2661707; identified by sequence similarity; putative. | Cysteine desulfurase; See PMID:20190049 for expression data; similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.914 |
AAO54949.1 | hscB | PSPTO_1428 | PSPTO_1426 | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.986 |
AAO54949.1 | iscA | PSPTO_1428 | PSPTO_1425 | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.961 |
AAO54949.1 | iscS-1 | PSPTO_1428 | PSPTO_0272 | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | Cysteine desulfurase; Similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.844 |
AAO54949.1 | iscS-2 | PSPTO_1428 | PSPTO_1423 | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.943 |
AAO54949.1 | iscS-3 | PSPTO_1428 | PSPTO_3438 | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | Cysteine desulfurase; See PMID:20190049 for expression data; similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.851 |
AAO54949.1 | iscU | PSPTO_1428 | PSPTO_1424 | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | Iron-binding protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.987 |
hscB | AAO54949.1 | PSPTO_1426 | PSPTO_1428 | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | 0.986 |
hscB | iscA | PSPTO_1426 | PSPTO_1425 | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.991 |
hscB | iscS-1 | PSPTO_1426 | PSPTO_0272 | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Cysteine desulfurase; Similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.790 |
hscB | iscS-2 | PSPTO_1426 | PSPTO_1423 | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.946 |
hscB | iscS-3 | PSPTO_1426 | PSPTO_3438 | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Cysteine desulfurase; See PMID:20190049 for expression data; similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.795 |
hscB | iscU | PSPTO_1426 | PSPTO_1424 | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-binding protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.997 |
iscA | AAO54949.1 | PSPTO_1425 | PSPTO_1428 | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Ferredoxin, 2Fe-2S; See PMID:20190049 for expression data. | 0.961 |
iscA | hscB | PSPTO_1425 | PSPTO_1426 | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.991 |
iscA | iscS-1 | PSPTO_1425 | PSPTO_0272 | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Cysteine desulfurase; Similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.755 |
iscA | iscS-2 | PSPTO_1425 | PSPTO_1423 | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.909 |
iscA | iscS-3 | PSPTO_1425 | PSPTO_3438 | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Cysteine desulfurase; See PMID:20190049 for expression data; similar to SP:P39171, GB:D90244, and PID:216809; identified by sequence similarity; putative. | 0.765 |