node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO55791.1 | AAO56532.1 | PSPTO_2277 | PSPTO_3043 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 0.910 |
AAO55791.1 | AAO58479.1 | PSPTO_2277 | PSPTO_5051 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Ham1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
AAO55791.1 | AAO58825.1 | PSPTO_2277 | PSPTO_5403 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | 0.900 |
AAO55791.1 | guaA | PSPTO_2277 | PSPTO_1450 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.900 |
AAO55791.1 | guaB | PSPTO_2277 | PSPTO_1449 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.900 |
AAO55791.1 | hpt | PSPTO_2277 | PSPTO_1131 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Hypoxanthine phosphoribosyltransferase. | 0.900 |
AAO55791.1 | purA | PSPTO_2277 | PSPTO_4937 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.900 |
AAO55791.1 | purH | PSPTO_2277 | PSPTO_4866 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; See PMID:20190049 for expression data. | 0.900 |
AAO55791.1 | surE | PSPTO_2277 | PSPTO_1562 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AAO55791.1 | xpt | PSPTO_2277 | PSPTO_0112 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.900 |
AAO56532.1 | AAO55791.1 | PSPTO_3043 | PSPTO_2277 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | 0.910 |
AAO56532.1 | AAO58479.1 | PSPTO_3043 | PSPTO_5051 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Ham1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
AAO56532.1 | AAO58825.1 | PSPTO_3043 | PSPTO_5403 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | HAD-superfamily hydrolase; See PMID:20190049 for expression data; identified by match to TIGR protein family HMM TIGR01454. | 0.900 |
AAO56532.1 | guaA | PSPTO_3043 | PSPTO_1450 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.900 |
AAO56532.1 | guaB | PSPTO_3043 | PSPTO_1449 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.900 |
AAO56532.1 | hpt | PSPTO_3043 | PSPTO_1131 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Hypoxanthine phosphoribosyltransferase. | 0.900 |
AAO56532.1 | purA | PSPTO_3043 | PSPTO_4937 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.900 |
AAO56532.1 | purH | PSPTO_3043 | PSPTO_4866 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; See PMID:20190049 for expression data. | 0.900 |
AAO56532.1 | surE | PSPTO_3043 | PSPTO_1562 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AAO56532.1 | xpt | PSPTO_3043 | PSPTO_0112 | 5'-nucleotidase, putative; Similar to GP:12659324; identified by sequence similarity; putative. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.900 |