node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO55222.1 | AAO55223.1 | PSPTO_1702 | PSPTO_1703 | Permease, putative; See PMID:20190049 for expression data. | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | 0.560 |
AAO55222.1 | cobB2 | PSPTO_1702 | PSPTO_1704 | Permease, putative; See PMID:20190049 for expression data. | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. | 0.420 |
AAO55223.1 | AAO55222.1 | PSPTO_1703 | PSPTO_1702 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | Permease, putative; See PMID:20190049 for expression data. | 0.560 |
AAO55223.1 | AAO55225.1 | PSPTO_1703 | PSPTO_1705 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | NLP/P60 family protein; See PMID:20190049 for expression data. | 0.603 |
AAO55223.1 | cobB2 | PSPTO_1703 | PSPTO_1704 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. | 0.761 |
AAO55223.1 | dnaA | PSPTO_1703 | PSPTO_0001 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.587 |
AAO55223.1 | dnaB | PSPTO_1703 | PSPTO_4929 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.663 |
AAO55223.1 | dnaN | PSPTO_1703 | PSPTO_0002 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.966 |
AAO55223.1 | polI | PSPTO_1703 | PSPTO_0344 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.601 |
AAO55223.1 | recF | PSPTO_1703 | PSPTO_0003 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.822 |
AAO55223.1 | rpmE-1 | PSPTO_1703 | PSPTO_4183 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | Ribosomal protein L31; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF01197. | 0.593 |
AAO55223.1 | topA | PSPTO_1703 | PSPTO_3514 | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.540 |
AAO55225.1 | AAO55223.1 | PSPTO_1705 | PSPTO_1703 | NLP/P60 family protein; See PMID:20190049 for expression data. | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | 0.603 |
AAO55225.1 | cobB2 | PSPTO_1705 | PSPTO_1704 | NLP/P60 family protein; See PMID:20190049 for expression data. | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. | 0.587 |
cobB2 | AAO55222.1 | PSPTO_1704 | PSPTO_1702 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. | Permease, putative; See PMID:20190049 for expression data. | 0.420 |
cobB2 | AAO55223.1 | PSPTO_1704 | PSPTO_1703 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | 0.761 |
cobB2 | AAO55225.1 | PSPTO_1704 | PSPTO_1705 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily. | NLP/P60 family protein; See PMID:20190049 for expression data. | 0.587 |
dnaA | AAO55223.1 | PSPTO_0001 | PSPTO_1703 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DnaA family protein; See PMID:20190049 for expression data; Belongs to the DnaA family. HdA subfamily. | 0.587 |
dnaA | dnaB | PSPTO_0001 | PSPTO_4929 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.925 |
dnaA | dnaN | PSPTO_0001 | PSPTO_0002 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.982 |