node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO57366.1 | mscL | PSPTO_3900 | PSPTO_4641 | Sensory box histidine kinase/response regulator; Similar to GP:14626713; identified by sequence similarity; putative. | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.514 |
AAO57366.1 | polI | PSPTO_3900 | PSPTO_0344 | Sensory box histidine kinase/response regulator; Similar to GP:14626713; identified by sequence similarity; putative. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.543 |
metK | mscL | PSPTO_0383 | PSPTO_4641 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.674 |
metK | polI | PSPTO_0383 | PSPTO_0344 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.463 |
metK | ribH-1 | PSPTO_0383 | PSPTO_0693 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.690 |
metK | ribH-2 | PSPTO_0383 | PSPTO_1839 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.690 |
metK | trpS | PSPTO_0383 | PSPTO_4429 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.733 |
modC | mscL | PSPTO_2975 | PSPTO_4641 | Molybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.516 |
modC | rpmH | PSPTO_2975 | PSPTO_5615 | Molybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. | Ribosomal protein L34; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00468; Belongs to the bacterial ribosomal protein bL34 family. | 0.497 |
modC | trpB | PSPTO_2975 | PSPTO_0158 | Molybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.471 |
mscL | AAO57366.1 | PSPTO_4641 | PSPTO_3900 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Sensory box histidine kinase/response regulator; Similar to GP:14626713; identified by sequence similarity; putative. | 0.514 |
mscL | metK | PSPTO_4641 | PSPTO_0383 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.674 |
mscL | modC | PSPTO_4641 | PSPTO_2975 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Molybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. | 0.516 |
mscL | polI | PSPTO_4641 | PSPTO_0344 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.500 |
mscL | radA | PSPTO_4641 | PSPTO_4640 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.525 |
mscL | ribH-1 | PSPTO_4641 | PSPTO_0693 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.650 |
mscL | ribH-2 | PSPTO_4641 | PSPTO_1839 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.650 |
mscL | rpmH | PSPTO_4641 | PSPTO_5615 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Ribosomal protein L34; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00468; Belongs to the bacterial ribosomal protein bL34 family. | 0.519 |
mscL | trpB | PSPTO_4641 | PSPTO_0158 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.478 |
mscL | trpS | PSPTO_4641 | PSPTO_4429 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.486 |