STRINGSTRING
trpC trpC AEG30877.1 AEG30877.1 trpF trpF trpB trpB trpE trpE trpD trpD trpA trpA AEG31907.1 AEG31907.1 AEG31558.1 AEG31558.1 AEG30874.1 AEG30874.1 gph gph
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
trpCKEGG: psa:PST_0747 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (268 aa)    
Predicted Functional Partners:
AEG30877.1
TIGRFAM: Glutamine amidotransferase of anthranilate synthase; KEGG: tcx:Tcr_0267 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
  
 0.999
trpF
Phosphoribosylanthranilate isomerase; KEGG: nve:NEMVE_v1g145157 hypothetical protein; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family.
 
 0.999
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 0.999
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 0.998
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 0.998
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 
 0.998
AEG31907.1
Anthranilate synthase; KEGG: tcx:Tcr_0715 hypothetical protein; PFAM: Chorismate binding, C-terminal; Anthranilate synthase component I, N-terminal.
 
 0.975
AEG31558.1
PFAM: Glycosyl transferase, family 3, N-terminal; KEGG: tcx:Tcr_1161 hypothetical protein.
 
  
 0.824
AEG30874.1
TIGRFAM: Ribulose-phosphate 3-epimerase; KEGG: tcx:Tcr_0264 ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.
     
 0.803
gph
Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
       0.797
Your Current Organism:
Thiomicrospira cyclica
NCBI taxonomy Id: 717773
Other names: T. cyclica ALM1, Thioalkalimicrobium cyclicum ALM1, Thiomicrospira cyclica ALM1
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