STRINGSTRING
AFY17352.1 AFY17352.1 AFY17350.1 AFY17350.1 AFY17351.1 AFY17351.1 ftsH ftsH grpE grpE AFY22092.1 AFY22092.1 AFY17349.1 AFY17349.1 kefB kefB AFY18488.1 AFY18488.1 AFY19507.1 AFY19507.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AFY17352.1Peptidase; [O] COG0501 Zn-dependent protease with chaperone function. (451 aa)    
Predicted Functional Partners:
AFY17350.1
Hypothetical protein.
       0.779
AFY17351.1
Hypothetical protein.
       0.773
ftsH
ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.511
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
  
  
 0.486
AFY22092.1
Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases.
  
   
 0.479
AFY17349.1
Hypothetical protein.
       0.436
kefB
Glutathione-regulated potassium-efflux system protein; [P] COG0475 Kef-type K+ transport systems, membrane components; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
  
  
 0.421
AFY18488.1
Peptidase M48, Ste24p; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
 
  
 0.418
AFY19507.1
[R] COG0670 Integral membrane protein, interacts with FtsH; Belongs to the BI1 family.
  
  
 0.417
Your Current Organism:
Pseudomonas sp. UW4
NCBI taxonomy Id: 1207075
Other names: P. sp. UW4
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