STRINGSTRING
iscS1 iscS1 iscU iscU thiI thiI hscB hscB fdx fdx AFY18489.1 AFY18489.1 sirA sirA AFY19323.1 AFY19323.1 moeB moeB iscA iscA cyaY cyaY
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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iscS1Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa)    
Predicted Functional Partners:
iscU
FeS cluster assembly scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.997
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.980
hscB
Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.968
fdx
Ferredoxin, 2Fe-2S type, ISC system; [C] COG0633 Ferredoxin.
 
 0.966
AFY18489.1
SirA family protein; [O] COG0425 Predicted redox protein, regulator of disulfide bond formation; Belongs to the sulfur carrier protein TusA family.
   
 0.962
sirA
Sulfur transfer protein SirA; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family.
   
 0.962
AFY19323.1
ThiF family protein; [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
   
 0.958
moeB
Molybdopterin biosynthesis protein MoeB; [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
   
 0.958
iscA
Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family.
 
  
 0.941
cyaY
Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 0.930
Your Current Organism:
Pseudomonas sp. UW4
NCBI taxonomy Id: 1207075
Other names: P. sp. UW4
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