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mnmC mnmC soxA soxA sdhD sdhD thiI thiI alr alr asnB asnB smtA smtA cphA cphA rlmN rlmN trmE trmE AFY18546.1 AFY18546.1
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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mnmC5-methylaminomethyl-2-thiouridine methyltransferase; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (659 aa)    
Predicted Functional Partners:
soxA
Sarcosine oxidase, alpha subunit; [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family.
  
 
 0.740
sdhD
Succinate dehydrogenase subunit D; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
    0.557
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
   
 0.522
alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
  
 0.517
asnB
[E] COG0367 Asparagine synthase (glutamine-hydrolyzing).
  
  
 0.514
smtA
S-adenosylmethionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
  
 
 
 0.511
cphA
Cyanophycin synthetase, acetyltransferase; [M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes.
     
 0.511
rlmN
Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
 
  
 0.500
trmE
tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
  
  
 0.498
AFY18546.1
polyphosphate:AMP phosphotransferase; [S] COG2326 Uncharacterized conserved protein.
       0.470
Your Current Organism:
Pseudomonas sp. UW4
NCBI taxonomy Id: 1207075
Other names: P. sp. UW4
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