node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFY18037.1 | lexA2 | PputUW4_00830 | PputUW4_03516 | YebG family protein; [S] COG3141 Uncharacterized protein conserved in bacteria. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.618 |
AFY18037.1 | recA | PputUW4_00830 | PputUW4_01125 | YebG family protein; [S] COG3141 Uncharacterized protein conserved in bacteria. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.484 |
AFY18037.1 | recN | PputUW4_00830 | PputUW4_00688 | YebG family protein; [S] COG3141 Uncharacterized protein conserved in bacteria. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.543 |
AFY18037.1 | sulA | PputUW4_00830 | PputUW4_03517 | YebG family protein; [S] COG3141 Uncharacterized protein conserved in bacteria. | SOS cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.823 |
AFY19527.1 | AFY19528.1 | PputUW4_02328 | PputUW4_02329 | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | 0.995 |
AFY19527.1 | dinB | PputUW4_02328 | PputUW4_01144 | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.784 |
AFY19527.1 | dnaE2 | PputUW4_02328 | PputUW4_02330 | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.970 |
AFY19527.1 | lexA2 | PputUW4_02328 | PputUW4_03516 | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.607 |
AFY19527.1 | recN | PputUW4_02328 | PputUW4_00688 | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.453 |
AFY19528.1 | AFY19527.1 | PputUW4_02329 | PputUW4_02328 | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | 0.995 |
AFY19528.1 | dnaE2 | PputUW4_02329 | PputUW4_02330 | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.972 |
AFY19528.1 | lexA2 | PputUW4_02329 | PputUW4_03516 | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.700 |
AFY19528.1 | recA | PputUW4_02329 | PputUW4_01125 | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.757 |
AFY19528.1 | recN | PputUW4_02329 | PputUW4_00688 | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.453 |
AFY19528.1 | sulA | PputUW4_02329 | PputUW4_03517 | Hypothetical protein; [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | SOS cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.418 |
AFY20708.1 | lexA2 | PputUW4_03515 | PputUW4_03516 | [K] COG1309 Transcriptional regulator. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.544 |
AFY20708.1 | sulA | PputUW4_03515 | PputUW4_03517 | [K] COG1309 Transcriptional regulator. | SOS cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.543 |
dinB | AFY19527.1 | PputUW4_01144 | PputUW4_02328 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Hypothetical protein; [L] COG0468 RecA/RadA recombinase. | 0.784 |
dinB | dnaE2 | PputUW4_01144 | PputUW4_02330 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.510 |
dinB | lexA2 | PputUW4_01144 | PputUW4_03516 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.739 |