node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobB | cobC2 | PputUW4_03774 | PputUW4_03771 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.948 |
cobB | cobD | PputUW4_03774 | PputUW4_03772 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.977 |
cobB | cobH | PputUW4_03774 | PputUW4_00539 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-8X methylmutase; [H] COG2082 Precorrin isomerase. | 0.994 |
cobB | cobJ | PputUW4_03774 | PputUW4_00541 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | [H] COG1010 Precorrin-3B methylase. | 0.951 |
cobB | cobM | PputUW4_03774 | PputUW4_02357 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | [H] COG2875 Precorrin-4 methylase. | 0.898 |
cobB | cobO | PputUW4_03774 | PputUW4_03775 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.993 |
cobB | cobQ | PputUW4_03774 | PputUW4_03770 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.989 |
cobB | cobS | PputUW4_03774 | PputUW4_03766 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.922 |
cobB | cobT | PputUW4_03774 | PputUW4_03768 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.971 |
cobB | cobU | PputUW4_03774 | PputUW4_03769 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.965 |
cobC2 | cobB | PputUW4_03771 | PputUW4_03774 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.948 |
cobC2 | cobD | PputUW4_03771 | PputUW4_03772 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.996 |
cobC2 | cobH | PputUW4_03771 | PputUW4_00539 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | precorrin-8X methylmutase; [H] COG2082 Precorrin isomerase. | 0.497 |
cobC2 | cobJ | PputUW4_03771 | PputUW4_00541 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | [H] COG1010 Precorrin-3B methylase. | 0.635 |
cobC2 | cobM | PputUW4_03771 | PputUW4_02357 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | [H] COG2875 Precorrin-4 methylase. | 0.461 |
cobC2 | cobO | PputUW4_03771 | PputUW4_03775 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.993 |
cobC2 | cobQ | PputUW4_03771 | PputUW4_03770 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.995 |
cobC2 | cobS | PputUW4_03771 | PputUW4_03766 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.872 |
cobC2 | cobT | PputUW4_03771 | PputUW4_03768 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.900 |
cobC2 | cobU | PputUW4_03771 | PputUW4_03769 | Threonine-phosphate decarboxylase; [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.991 |