node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFY22022.1 | AFY22023.1 | PputUW4_04832 | PputUW4_04833 | [S] COG3126 Uncharacterized protein conserved in bacteria. | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | 0.825 |
AFY22022.1 | nrdR | PputUW4_04832 | PputUW4_04831 | [S] COG3126 Uncharacterized protein conserved in bacteria. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.625 |
AFY22022.1 | ribBA3 | PputUW4_04832 | PputUW4_04828 | [S] COG3126 Uncharacterized protein conserved in bacteria. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.530 |
AFY22022.1 | ribD | PputUW4_04832 | PputUW4_04830 | [S] COG3126 Uncharacterized protein conserved in bacteria. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.622 |
AFY22022.1 | ribE | PputUW4_04832 | PputUW4_04829 | [S] COG3126 Uncharacterized protein conserved in bacteria. | [H] COG0307 Riboflavin synthase alpha chain. | 0.525 |
AFY22023.1 | AFY22022.1 | PputUW4_04833 | PputUW4_04832 | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | [S] COG3126 Uncharacterized protein conserved in bacteria. | 0.825 |
AFY22023.1 | nrdR | PputUW4_04833 | PputUW4_04831 | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.604 |
AFY22023.1 | ribBA3 | PputUW4_04833 | PputUW4_04828 | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.532 |
AFY22023.1 | ribD | PputUW4_04833 | PputUW4_04830 | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.623 |
AFY22023.1 | ribE | PputUW4_04833 | PputUW4_04829 | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | [H] COG0307 Riboflavin synthase alpha chain. | 0.525 |
birA | nrdA | PputUW4_04900 | PputUW4_04133 | Bifunctional protein biotin operon repressor/ biotin-[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.411 |
birA | nrdR | PputUW4_04900 | PputUW4_04831 | Bifunctional protein biotin operon repressor/ biotin-[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.589 |
birA | ribBA3 | PputUW4_04900 | PputUW4_04828 | Bifunctional protein biotin operon repressor/ biotin-[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.565 |
birA | ribD | PputUW4_04900 | PputUW4_04830 | Bifunctional protein biotin operon repressor/ biotin-[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.601 |
nrdA | birA | PputUW4_04133 | PputUW4_04900 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Bifunctional protein biotin operon repressor/ biotin-[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.411 |
nrdA | nrdR | PputUW4_04133 | PputUW4_04831 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.572 |
nrdA | ribD | PputUW4_04133 | PputUW4_04830 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.498 |
nrdR | AFY22022.1 | PputUW4_04831 | PputUW4_04832 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | [S] COG3126 Uncharacterized protein conserved in bacteria. | 0.625 |
nrdR | AFY22023.1 | PputUW4_04831 | PputUW4_04833 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Type 12 methyltransferase; [R] COG3897 Predicted methyltransferase. | 0.604 |
nrdR | birA | PputUW4_04831 | PputUW4_04900 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Bifunctional protein biotin operon repressor/ biotin-[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.589 |