node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFY22092.1 | amiC | PputUW4_04902 | PputUW4_00449 | Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases. | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | 0.698 |
AFY22092.1 | anmK | PputUW4_04902 | PputUW4_04903 | Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.884 |
AFY22092.1 | mltG | PputUW4_04902 | PputUW4_04029 | Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.533 |
AFY22092.1 | tyrS | PputUW4_04902 | PputUW4_04901 | Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases. | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. | 0.629 |
amiC | AFY22092.1 | PputUW4_00449 | PputUW4_04902 | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases. | 0.698 |
amiC | ampD | PputUW4_00449 | PputUW4_00714 | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | N-acetyl-anhydromuranmyl-L-alanine amidase; [V] COG3023 Negative regulator of beta-lactamase expression. | 0.421 |
amiC | anmK | PputUW4_00449 | PputUW4_04903 | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.428 |
amiC | mltG | PputUW4_00449 | PputUW4_04029 | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.560 |
amiC | nagZ | PputUW4_00449 | PputUW4_03514 | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.491 |
ampD | amiC | PputUW4_00714 | PputUW4_00449 | N-acetyl-anhydromuranmyl-L-alanine amidase; [V] COG3023 Negative regulator of beta-lactamase expression. | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | 0.421 |
ampD | anmK | PputUW4_00714 | PputUW4_04903 | N-acetyl-anhydromuranmyl-L-alanine amidase; [V] COG3023 Negative regulator of beta-lactamase expression. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.430 |
anmK | AFY22092.1 | PputUW4_04903 | PputUW4_04902 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Peptidase M23B; [M] COG0739 Membrane proteins related to metalloendopeptidases. | 0.884 |
anmK | amiC | PputUW4_04903 | PputUW4_00449 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | [M] COG0860 N-acetylmuramoyl-L-alanine amidase. | 0.428 |
anmK | ampD | PputUW4_04903 | PputUW4_00714 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetyl-anhydromuranmyl-L-alanine amidase; [V] COG3023 Negative regulator of beta-lactamase expression. | 0.430 |
anmK | mltG | PputUW4_04903 | PputUW4_04029 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.430 |
anmK | murB | PputUW4_04903 | PputUW4_04047 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.409 |
anmK | nagA | PputUW4_04903 | PputUW4_00969 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | [G] COG1820 N-acetylglucosamine-6-phosphate deacetylase. | 0.442 |
anmK | nagZ | PputUW4_04903 | PputUW4_03514 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.596 |
anmK | pgl | PputUW4_04903 | PputUW4_04249 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.418 |
anmK | ribD | PputUW4_04903 | PputUW4_04830 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.517 |