node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFY18653.1 | AFY20662.1 | PputUW4_01447 | PputUW4_03469 | [T] COG1956 GAF domain-containing protein. | [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase. | 0.903 |
AFY18653.1 | metE | PputUW4_01447 | PputUW4_02038 | [T] COG1956 GAF domain-containing protein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |
AFY18653.1 | metH | PputUW4_01447 | PputUW4_02354 | [T] COG1956 GAF domain-containing protein. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
AFY18653.1 | metK | PputUW4_01447 | PputUW4_05068 | [T] COG1956 GAF domain-containing protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
AFY20662.1 | AFY18653.1 | PputUW4_03469 | PputUW4_01447 | [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase. | [T] COG1956 GAF domain-containing protein. | 0.903 |
AFY20662.1 | metE | PputUW4_03469 | PputUW4_02038 | [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.908 |
AFY20662.1 | metH | PputUW4_03469 | PputUW4_02354 | [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.917 |
AFY20662.1 | metK | PputUW4_03469 | PputUW4_05068 | [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.908 |
AFY20662.1 | tpiA | PputUW4_03469 | PputUW4_00702 | [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.466 |
AFY21380.1 | ahcY | PputUW4_04188 | PputUW4_05078 | Cytosine-specific methyltransferase; [L] COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.912 |
AFY21380.1 | metK | PputUW4_04188 | PputUW4_05068 | Cytosine-specific methyltransferase; [L] COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.933 |
AFY21380.1 | speD | PputUW4_04188 | PputUW4_04913 | Cytosine-specific methyltransferase; [L] COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.900 |
AFY22257.1 | ahcY | PputUW4_05067 | PputUW4_05078 | ArsR family transcriptional regulator; [QR] COG0500 SAM-dependent methyltransferases. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.410 |
AFY22257.1 | metH | PputUW4_05067 | PputUW4_02354 | ArsR family transcriptional regulator; [QR] COG0500 SAM-dependent methyltransferases. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.510 |
AFY22257.1 | metK | PputUW4_05067 | PputUW4_05068 | ArsR family transcriptional regulator; [QR] COG0500 SAM-dependent methyltransferases. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.833 |
ahcY | AFY21380.1 | PputUW4_05078 | PputUW4_04188 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cytosine-specific methyltransferase; [L] COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.912 |
ahcY | AFY22257.1 | PputUW4_05078 | PputUW4_05067 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | ArsR family transcriptional regulator; [QR] COG0500 SAM-dependent methyltransferases. | 0.410 |
ahcY | guaA1 | PputUW4_05078 | PputUW4_00980 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.488 |
ahcY | metE | PputUW4_05078 | PputUW4_02038 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.974 |
ahcY | metH | PputUW4_05078 | PputUW4_02354 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.959 |