STRINGSTRING
metX metX metW metW AFY21619.1 AFY21619.1 metZ metZ AFY19839.1 AFY19839.1 AFY19844.1 AFY19844.1 AFY20356.1 AFY20356.1 glyA1 glyA1 glyA2 glyA2 glyA3 glyA3 AFY19129.1 AFY19129.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
metXHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (379 aa)    
Predicted Functional Partners:
metW
Methionine biosynthesis protein MetW; [QR] COG0500 SAM-dependent methyltransferases.
  
 0.997
AFY21619.1
[E] COG0460 Homoserine dehydrogenase.
 
 0.964
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
 
  
 0.952
AFY19839.1
[E] COG0460 Homoserine dehydrogenase.
 
 
 0.939
AFY19844.1
[E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
 
  
 0.938
AFY20356.1
Cystathionine beta-synthase; [E] COG0031 Cysteine synthase.
  
 
 0.848
glyA1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.828
glyA2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.828
glyA3
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.828
AFY19129.1
Pyridoxal-5'-phosphate-dependent protein beta subunit; [E] COG1171 Threonine dehydratase.
  
 
 0.827
Your Current Organism:
Pseudomonas sp. UW4
NCBI taxonomy Id: 1207075
Other names: P. sp. UW4
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