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ilvA2 ilvA2 ilvH ilvH leuB leuB AFY19841.1 AFY19841.1 thrC thrC ilvB ilvB trpB trpB AFY18084.1 AFY18084.1 AFY21547.1 AFY21547.1 AFY20356.1 AFY20356.1 AFY19129.1 AFY19129.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ilvA2Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)    
Predicted Functional Partners:
ilvH
[E] COG0440 Acetolactate synthase, small (regulatory) subunit.
 
 
 0.953
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
 0.949
AFY19841.1
[E] COG0498 Threonine synthase.
  
 
 0.938
thrC
[E] COG0498 Threonine synthase.
  
 
 0.938
ilvB
Acetolactate synthase 3 catalytic subunit; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase].
 
 0.936
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.929
AFY18084.1
Putative acetolactate synthase large subunit; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family.
  
 0.926
AFY21547.1
Acetolactate synthase large subunit; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family.
  
 0.926
AFY20356.1
Cystathionine beta-synthase; [E] COG0031 Cysteine synthase.
  
 
0.925
AFY19129.1
Pyridoxal-5'-phosphate-dependent protein beta subunit; [E] COG1171 Threonine dehydratase.
  
  
 
0.922
Your Current Organism:
Pseudomonas sp. UW4
NCBI taxonomy Id: 1207075
Other names: P. sp. UW4
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