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hemC hemC hemD hemD hemB1 hemB1 hemB2 hemB2 hemE hemE cobA2 cobA2 hemA hemA cobA1 cobA1 hemL hemL hemX hemX hemY hemY
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textmining
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hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)    
Predicted Functional Partners:
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.997
hemB1
[H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
hemB2
[H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.983
cobA2
uroporphyrin-III C-methyltransferase; [H] COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family.
  
 0.982
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.979
cobA1
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 0.970
hemL
[H] COG0001 Glutamate-1-semialdehyde aminotransferase.
 
  
 0.934
hemX
uroporphyrin-III C-methyltransferase; [H] COG2959 Uncharacterized enzyme of heme biosynthesis.
  
  
 0.869
hemY
HemY protein; [H] COG3071 Uncharacterized enzyme of heme biosynthesis.
  
  
 0.825
Your Current Organism:
Pseudomonas sp. UW4
NCBI taxonomy Id: 1207075
Other names: P. sp. UW4
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