STRINGSTRING
mutM mutM polA polA coaE coaE AEF22047.1 AEF22047.1 uvrC uvrC nth nth AEF20151.1 AEF20151.1 AEF20150.1 AEF20150.1 AEF23881.1 AEF23881.1 AEF23137.1 AEF23137.1 AEF20153.1 AEF20153.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mutMFormamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (270 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.975
coaE
Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.950
AEF22047.1
DEAD/H associated domain protein; KEGG: psa:PST_2663 DEAD-box ATP dependent DNA helicase; PFAM: DEAD/H associated; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal.
  
  
 0.821
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.748
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.723
AEF20151.1
Putative signal transduction protein; PFAM: Metal-dependent hydrolase HDOD; KEGG: pap:PSPA7_0449 hypothetical protein.
       0.712
AEF20150.1
Intracellular protease, PfpI family; KEGG: psa:PST_4009 protease PfpI; TIGRFAM: Peptidase C56, PfpI; PFAM: ThiJ/PfpI.
     
 0.710
AEF23881.1
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
  
  
 0.685
AEF23137.1
KEGG: pfs:PFLU3613 hypothetical protein.
   
  
 0.634
AEF20153.1
KEGG: psa:PST_4006 cation/multidrug efflux pump.
       0.575
Your Current Organism:
Pseudomonas fulva
NCBI taxonomy Id: 743720
Other names: P. fulva 12-X, Pseudomonas fulva 12-X, Pseudomonas fulva str. 12-X, Pseudomonas fulva strain 12-X
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