node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEF19989.1 | AEF21483.1 | Psefu_0002 | Psefu_1507 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | 0.981 |
AEF19989.1 | AEF24048.1 | Psefu_0002 | Psefu_4093 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.591 |
AEF19989.1 | dnaA | Psefu_0002 | Psefu_0001 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.995 |
AEF19989.1 | polA | Psefu_0002 | Psefu_4313 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.998 |
AEF19989.1 | recF | Psefu_0002 | Psefu_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.946 |
AEF19989.1 | rnpA | Psefu_0002 | Psefu_4495 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.684 |
AEF19989.1 | topA | Psefu_0002 | Psefu_2915 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.703 |
AEF20665.1 | AEF21483.1 | Psefu_0687 | Psefu_1507 | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: pmy:Pmen_3856 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | 0.608 |
AEF20665.1 | rpmE | Psefu_0687 | Psefu_0417 | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: pmy:Pmen_3856 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. | 50S ribosomal protein L31; Binds the 23S rRNA. | 0.792 |
AEF21482.1 | AEF21483.1 | Psefu_1506 | Psefu_1507 | Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: pen:PSEEN1372 permease. | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | 0.633 |
AEF21483.1 | AEF19989.1 | Psefu_1507 | Psefu_0002 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.981 |
AEF21483.1 | AEF20665.1 | Psefu_1507 | Psefu_0687 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: pmy:Pmen_3856 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. | 0.608 |
AEF21483.1 | AEF21482.1 | Psefu_1507 | Psefu_1506 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: pen:PSEEN1372 permease. | 0.633 |
AEF21483.1 | AEF24048.1 | Psefu_1507 | Psefu_4093 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.701 |
AEF21483.1 | dnaA | Psefu_1507 | Psefu_0001 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.602 |
AEF21483.1 | polA | Psefu_1507 | Psefu_4313 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.684 |
AEF21483.1 | recF | Psefu_1507 | Psefu_0003 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.845 |
AEF21483.1 | rnpA | Psefu_1507 | Psefu_4495 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.626 |
AEF21483.1 | rpmE | Psefu_1507 | Psefu_0417 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | 50S ribosomal protein L31; Binds the 23S rRNA. | 0.795 |
AEF21483.1 | topA | Psefu_1507 | Psefu_2915 | DnaA regulatory inactivator Hda; KEGG: pmy:Pmen_2993 DNA replication initiation factor; TIGRFAM: Chromosomal replication control, regulator Hda; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Belongs to the DnaA family. HdA subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.545 |