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phnN phnN prs prs pyrE pyrE purF purF hisG hisG hisZ hisZ phnC phnC AEF21553.1 AEF21553.1 AEF21551.1 AEF21551.1 AEF21550.1 AEF21550.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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phnNPhosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (186 aa)    
Predicted Functional Partners:
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
     
  0.900
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
     
  0.800
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
  0.800
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
     
  0.800
hisZ
ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
     
  0.800
phnC
Phosphonate-transporting ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
 
  
 0.691
AEF21553.1
KEGG: psb:Psyr_0695 extracellular solute-binding protein; TIGRFAM: Phosphonate-binding periplasmic protein; SMART: Extracellular solute-binding protein, family 3.
 
  
 0.668
AEF21551.1
KEGG: psp:PSPPH_0704 phosphonate ABC transporter, permease protein, putative; TIGRFAM: Phosphonate uptake transporter; PFAM: Binding-protein-dependent transport systems inner membrane component.
 
  
 0.612
AEF21550.1
Phosphonate ABC transporter, inner membrane subunit; KEGG: psb:Psyr_0692 binding-protein dependent transport system inner membrane protein; TIGRFAM: Phosphonate uptake transporter; PFAM: Binding-protein-dependent transport systems inner membrane component.
 
  
 0.589
Your Current Organism:
Pseudomonas fulva
NCBI taxonomy Id: 743720
Other names: P. fulva 12-X, Pseudomonas fulva 12-X, Pseudomonas fulva str. 12-X, Pseudomonas fulva strain 12-X
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