node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEF20906.1 | AEF23264.1 | Psefu_0928 | Psefu_3302 | UBA/THIF-type NAD/FAD binding protein; KEGG: pmy:Pmen_1062 molybdopterin biosynthesis protein MoeB; manually curated; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.517 |
AEF20906.1 | iscS | Psefu_0928 | Psefu_3303 | UBA/THIF-type NAD/FAD binding protein; KEGG: pmy:Pmen_1062 molybdopterin biosynthesis protein MoeB; manually curated; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.986 |
AEF20906.1 | thiI | Psefu_0928 | Psefu_3895 | UBA/THIF-type NAD/FAD binding protein; KEGG: pmy:Pmen_1062 molybdopterin biosynthesis protein MoeB; manually curated; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB. | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.544 |
AEF21518.1 | iscS | Psefu_1542 | Psefu_3303 | PFAM: SirA-like; KEGG: nve:NEMVE_v1g151714 hypothetical protein; Belongs to the sulfur carrier protein TusA family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.975 |
AEF21518.1 | thiI | Psefu_1542 | Psefu_3895 | PFAM: SirA-like; KEGG: nve:NEMVE_v1g151714 hypothetical protein; Belongs to the sulfur carrier protein TusA family. | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.489 |
AEF21518.1 | tusA | Psefu_1542 | Psefu_2846 | PFAM: SirA-like; KEGG: nve:NEMVE_v1g151714 hypothetical protein; Belongs to the sulfur carrier protein TusA family. | Sulfurtransferase tusA; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. | 0.913 |
AEF23260.1 | AEF23263.1 | Psefu_3298 | Psefu_3301 | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.980 |
AEF23260.1 | AEF23264.1 | Psefu_3298 | Psefu_3302 | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.993 |
AEF23260.1 | AEF23266.1 | Psefu_3298 | Psefu_3304 | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.788 |
AEF23260.1 | cyaY | Psefu_3298 | Psefu_0384 | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | Protein cyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.917 |
AEF23260.1 | hscB | Psefu_3298 | Psefu_3300 | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | Co-chaperone protein hscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.993 |
AEF23260.1 | iscS | Psefu_3298 | Psefu_3303 | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.982 |
AEF23263.1 | AEF23260.1 | Psefu_3301 | Psefu_3298 | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | 0.980 |
AEF23263.1 | AEF23264.1 | Psefu_3301 | Psefu_3302 | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.984 |
AEF23263.1 | AEF23266.1 | Psefu_3301 | Psefu_3304 | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.926 |
AEF23263.1 | cyaY | Psefu_3301 | Psefu_0384 | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Protein cyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.559 |
AEF23263.1 | hscB | Psefu_3301 | Psefu_3300 | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Co-chaperone protein hscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.987 |
AEF23263.1 | iscS | Psefu_3301 | Psefu_3303 | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.973 |
AEF23264.1 | AEF20906.1 | Psefu_3302 | Psefu_0928 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | UBA/THIF-type NAD/FAD binding protein; KEGG: pmy:Pmen_1062 molybdopterin biosynthesis protein MoeB; manually curated; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB. | 0.517 |
AEF23264.1 | AEF23260.1 | Psefu_3302 | Psefu_3298 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | KEGG: pmy:Pmen_3506 ferredoxin, 2Fe-2S type, ISC system; TIGRFAM: Ferredoxin, 2Fe-2S type; PFAM: Ferredoxin. | 0.993 |