node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Psyr_0059 | Psyr_0060 | Psyr_0059 | Psyr_0060 | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | Protein of unknown function DUF513. | 0.976 |
Psyr_0059 | Psyr_0061 | Psyr_0059 | Psyr_0061 | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.919 |
Psyr_0059 | Psyr_1250 | Psyr_0059 | Psyr_1250 | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | Conserved hypothetical protein. | 0.667 |
Psyr_0059 | dsbB2 | Psyr_0059 | Psyr_0058 | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | Disulfide bond formation protein DsbB; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. | 0.732 |
Psyr_0059 | hemC | Psyr_0059 | Psyr_0062 | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.838 |
Psyr_0060 | Psyr_0059 | Psyr_0060 | Psyr_0059 | Protein of unknown function DUF513. | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | 0.976 |
Psyr_0060 | Psyr_0061 | Psyr_0060 | Psyr_0061 | Protein of unknown function DUF513. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.994 |
Psyr_0060 | Psyr_1250 | Psyr_0060 | Psyr_1250 | Protein of unknown function DUF513. | Conserved hypothetical protein. | 0.635 |
Psyr_0060 | Psyr_2098 | Psyr_0060 | Psyr_2098 | Protein of unknown function DUF513. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.904 |
Psyr_0060 | cysG | Psyr_0060 | Psyr_3174 | Protein of unknown function DUF513. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.910 |
Psyr_0060 | dsbB2 | Psyr_0060 | Psyr_0058 | Protein of unknown function DUF513. | Disulfide bond formation protein DsbB; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. | 0.650 |
Psyr_0060 | hemC | Psyr_0060 | Psyr_0062 | Protein of unknown function DUF513. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.864 |
Psyr_0060 | hemE | Psyr_0060 | Psyr_0414 | Protein of unknown function DUF513. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.908 |
Psyr_0061 | Psyr_0059 | Psyr_0061 | Psyr_0059 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal. | 0.919 |
Psyr_0061 | Psyr_0060 | Psyr_0061 | Psyr_0060 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Protein of unknown function DUF513. | 0.994 |
Psyr_0061 | Psyr_0292 | Psyr_0061 | Psyr_0292 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.818 |
Psyr_0061 | Psyr_1250 | Psyr_0061 | Psyr_1250 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein. | 0.632 |
Psyr_0061 | Psyr_2098 | Psyr_0061 | Psyr_2098 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.924 |
Psyr_0061 | TrkA | Psyr_0061 | Psyr_0016 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TrkA-N:TrkA-C. | 0.631 |
Psyr_0061 | cysG | Psyr_0061 | Psyr_3174 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.964 |