node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Psyr_0134 | Psyr_0951 | Psyr_0134 | Psyr_0951 | Aminotransferase, class V. | UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB. | 0.943 |
Psyr_0134 | Psyr_1236 | Psyr_0134 | Psyr_1236 | Aminotransferase, class V. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.754 |
Psyr_0134 | Psyr_1238 | Psyr_0134 | Psyr_1238 | Aminotransferase, class V. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.979 |
Psyr_0134 | Psyr_1239 | Psyr_0134 | Psyr_1239 | Aminotransferase, class V. | HesB/YadR/YfhF:Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.758 |
Psyr_0134 | Psyr_1242 | Psyr_0134 | Psyr_1242 | Aminotransferase, class V. | Ferredoxin, 2Fe-2S type. | 0.852 |
Psyr_0134 | Psyr_4756 | Psyr_0134 | Psyr_4756 | Aminotransferase, class V. | 3-mercaptopyruvate sulfurtransferase. | 0.914 |
Psyr_0134 | hscB | Psyr_0134 | Psyr_1240 | Aminotransferase, class V. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.793 |
Psyr_0134 | iscS | Psyr_0134 | Psyr_1237 | Aminotransferase, class V. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.904 |
Psyr_0134 | thiI | Psyr_0134 | Psyr_4816 | Aminotransferase, class V. | [ThiS-adenylate] sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.976 |
Psyr_0134 | tusA | Psyr_0134 | Psyr_1827 | Aminotransferase, class V. | SirA-like protein; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. | 0.953 |
Psyr_0951 | Psyr_0134 | Psyr_0951 | Psyr_0134 | UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB. | Aminotransferase, class V. | 0.943 |
Psyr_0951 | iscS | Psyr_0951 | Psyr_1237 | UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.943 |
Psyr_0951 | thiI | Psyr_0951 | Psyr_4816 | UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB. | [ThiS-adenylate] sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.531 |
Psyr_1236 | Psyr_0134 | Psyr_1236 | Psyr_0134 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Aminotransferase, class V. | 0.754 |
Psyr_1236 | Psyr_1238 | Psyr_1236 | Psyr_1238 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.959 |
Psyr_1236 | Psyr_1239 | Psyr_1236 | Psyr_1239 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | HesB/YadR/YfhF:Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.799 |
Psyr_1236 | Psyr_1242 | Psyr_1236 | Psyr_1242 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Ferredoxin, 2Fe-2S type. | 0.703 |
Psyr_1236 | hscB | Psyr_1236 | Psyr_1240 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.899 |
Psyr_1236 | iscS | Psyr_1236 | Psyr_1237 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.912 |
Psyr_1236 | thiI | Psyr_1236 | Psyr_4816 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | [ThiS-adenylate] sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.544 |