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topA topA Psyr_1522 Psyr_1522 Psyr_4518 Psyr_4518 leuS leuS Psyr_2914 Psyr_2914 GltB GltB Psyr_3738 Psyr_3738 Psyr_3804 Psyr_3804 Psyr_4948 Psyr_4948 Psyr_3286 Psyr_3286 rpoA rpoA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (870 aa)    
Predicted Functional Partners:
Psyr_1522
Single-strand binding protein.
  
 
 0.949
Psyr_4518
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
 
 0.949
leuS
leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.936
Psyr_2914
ATP-dependent DNA helicase RecQ.
  
 0.893
GltB
Glutamate synthase (NADPH) large subunit.
  
  
 0.872
Psyr_3738
ATP-dependent DNA helicase RecQ.
  
 0.850
Psyr_3804
ATP-dependent DNA helicase, RecQ-like protein.
  
 0.850
Psyr_4948
ATP-dependent DNA helicase, RecQ-like protein.
  
 0.850
Psyr_3286
Conserved hypothetical protein.
 
     0.846
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.815
Your Current Organism:
Pseudomonas syringae B728a
NCBI taxonomy Id: 205918
Other names: P. syringae pv. syringae B728a, Pseudomonas syringae pv. syringae B728a, Pseudomonas syringae pv. syringae str. B728a, Pseudomonas syringae pv. syringae strain B728a
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