node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHLH140 | F13F21.31 | Q9M041 | F4I1P7 | Transcription factor bHLH140. | DNA ligase. | 0.864 |
BHLH140 | FEN1 | Q9M041 | O65251 | Transcription factor bHLH140. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.691 |
BHLH140 | KU70 | Q9M041 | Q9FQ08 | Transcription factor bHLH140. | ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU80, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand. Belongs to the ku70 family. | 0.904 |
BHLH140 | LIG1 | Q9M041 | Q42572 | Transcription factor bHLH140. | DNA ligase 1; Essential protein. DNA ligase that seals nicks in double- stranded DNA during DNA replication, DNA recombination and DNA repair. Involved in repair of both single strand breaks (SSBs) and double strand breaks (DSBs). Required in the endosperm for embryogenesis, probably to repair DNA-breaks generated by DME. | 0.903 |
BHLH140 | LIG4 | Q9M041 | Q9LL84 | Transcription factor bHLH140. | DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair. May be involved for T-DNA integration even if not absolutely required. Seems to be dispensable under normal growth conditions. Belongs to the ATP-dependent DNA ligase family. | 0.965 |
BHLH140 | LIG6 | Q9M041 | F4HPZ9 | Transcription factor bHLH140. | DNA ligase 6; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (Probable). Required to maintain seed viability (e.g. longevity and storability) and during seed germination, probably by repairing DNA damage accumulated during seed development, storage and/or imbibition. Facilitates seed germination in cold conditions (2 degrees Celsius) and under oxidative stress (e.g. menadione, a genotoxic agent). Involved in repair of X- ray-induced damage ; Belongs to the ATP-dependent DNA ligase family. | 0.873 |
BHLH140 | OGG1 | Q9M041 | Q9FNY7 | Transcription factor bHLH140. | DNA-(apurinic or apyrimidinic site) lyase; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6- diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Belongs to the type-1 OGG1 family. | 0.855 |
BHLH140 | POLL | Q9M041 | Q9FNY4 | Transcription factor bHLH140. | DNA polymerase lambda; Repair polymerase involved in base excision repair (BER) and responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (By similarity). Involved in the repair of transposon-induced DNA double strand breaks (DSBs). Involved in repair of UV-B- mediated DNA damage during seedling development through an excision repair mechanism. Involved the repair of DSBs induced by high salinity and DNA cross-linking agent. Functions via the [...] | 0.975 |
BHLH140 | XRCC1 | Q9M041 | Q24JK4 | Transcription factor bHLH140. | DNA-repair protein XRCC1; Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity). Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation. | 0.999 |
BHLH140 | ZDP | Q9M041 | Q84JE8 | Transcription factor bHLH140. | Polynucleotide 3'-phosphatase ZDP; Nick-sensing 3'-phosphoesterase involved in a base excision repair pathway required for active DNA demethylation. The N-terminal DNA-binding domain binds specifically to gap sites and sharply bends the target DNA. Lacks 5'-kinase activity but is capable of 3'- phosphoglycolate end processing. Inactive on 3'-alpha,beta-unsaturated aldehyde (3'-dRP). Protects partially genes from transcriptional silencing by preventing promoter DNA hypermethylation. | 0.762 |
F13F21.31 | BHLH140 | F4I1P7 | Q9M041 | DNA ligase. | Transcription factor bHLH140. | 0.864 |
F13F21.31 | FEN1 | F4I1P7 | O65251 | DNA ligase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.967 |
F13F21.31 | KU70 | F4I1P7 | Q9FQ08 | DNA ligase. | ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU80, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand. Belongs to the ku70 family. | 0.974 |
F13F21.31 | LIG1 | F4I1P7 | Q42572 | DNA ligase. | DNA ligase 1; Essential protein. DNA ligase that seals nicks in double- stranded DNA during DNA replication, DNA recombination and DNA repair. Involved in repair of both single strand breaks (SSBs) and double strand breaks (DSBs). Required in the endosperm for embryogenesis, probably to repair DNA-breaks generated by DME. | 0.901 |
F13F21.31 | LIG4 | F4I1P7 | Q9LL84 | DNA ligase. | DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair. May be involved for T-DNA integration even if not absolutely required. Seems to be dispensable under normal growth conditions. Belongs to the ATP-dependent DNA ligase family. | 0.538 |
F13F21.31 | LIG6 | F4I1P7 | F4HPZ9 | DNA ligase. | DNA ligase 6; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (Probable). Required to maintain seed viability (e.g. longevity and storability) and during seed germination, probably by repairing DNA damage accumulated during seed development, storage and/or imbibition. Facilitates seed germination in cold conditions (2 degrees Celsius) and under oxidative stress (e.g. menadione, a genotoxic agent). Involved in repair of X- ray-induced damage ; Belongs to the ATP-dependent DNA ligase family. | 0.400 |
F13F21.31 | OGG1 | F4I1P7 | Q9FNY7 | DNA ligase. | DNA-(apurinic or apyrimidinic site) lyase; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6- diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Belongs to the type-1 OGG1 family. | 0.819 |
F13F21.31 | POLL | F4I1P7 | Q9FNY4 | DNA ligase. | DNA polymerase lambda; Repair polymerase involved in base excision repair (BER) and responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (By similarity). Involved in the repair of transposon-induced DNA double strand breaks (DSBs). Involved in repair of UV-B- mediated DNA damage during seedling development through an excision repair mechanism. Involved the repair of DSBs induced by high salinity and DNA cross-linking agent. Functions via the [...] | 0.962 |
F13F21.31 | XRCC1 | F4I1P7 | Q24JK4 | DNA ligase. | DNA-repair protein XRCC1; Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity). Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation. | 0.988 |
F13F21.31 | ZDP | F4I1P7 | Q84JE8 | DNA ligase. | Polynucleotide 3'-phosphatase ZDP; Nick-sensing 3'-phosphoesterase involved in a base excision repair pathway required for active DNA demethylation. The N-terminal DNA-binding domain binds specifically to gap sites and sharply bends the target DNA. Lacks 5'-kinase activity but is capable of 3'- phosphoglycolate end processing. Inactive on 3'-alpha,beta-unsaturated aldehyde (3'-dRP). Protects partially genes from transcriptional silencing by preventing promoter DNA hypermethylation. | 0.934 |