node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDIPT | CRLS1 | ENSP00000219789 | ENSP00000368140 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | 0.950 |
CDIPT | PLPPR1 | ENSP00000219789 | ENSP00000364008 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | 0.414 |
CDIPT | PLPPR3 | ENSP00000219789 | ENSP00000352962 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. | Phospholipid phosphatase-related protein type 3; Phospholipid phosphatase related 3. | 0.414 |
COQ2 | PLPPR1 | ENSP00000310873 | ENSP00000364008 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | 0.420 |
COQ2 | PLPPR3 | ENSP00000310873 | ENSP00000352962 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Phospholipid phosphatase-related protein type 3; Phospholipid phosphatase related 3. | 0.420 |
CRLS1 | CDIPT | ENSP00000368140 | ENSP00000219789 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. | 0.950 |
CRLS1 | PLPPR1 | ENSP00000368140 | ENSP00000364008 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | 0.402 |
CRLS1 | PLPPR3 | ENSP00000368140 | ENSP00000352962 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | Phospholipid phosphatase-related protein type 3; Phospholipid phosphatase related 3. | 0.402 |
JAG2 | PLPPR1 | ENSP00000328169 | ENSP00000364008 | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | 0.442 |
MRPL50 | PLPPR1 | ENSP00000363999 | ENSP00000364008 | Mitochondrial ribosomal protein L50. | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | 0.562 |
PLPPR1 | CDIPT | ENSP00000364008 | ENSP00000219789 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. | 0.414 |
PLPPR1 | COQ2 | ENSP00000364008 | ENSP00000310873 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.420 |
PLPPR1 | CRLS1 | ENSP00000364008 | ENSP00000368140 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | 0.402 |
PLPPR1 | JAG2 | ENSP00000364008 | ENSP00000328169 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | 0.442 |
PLPPR1 | MRPL50 | ENSP00000364008 | ENSP00000363999 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Mitochondrial ribosomal protein L50. | 0.562 |
PLPPR1 | PLPPR3 | ENSP00000364008 | ENSP00000352962 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Phospholipid phosphatase-related protein type 3; Phospholipid phosphatase related 3. | 0.590 |
PLPPR1 | RAB23 | ENSP00000364008 | ENSP00000417610 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 pr [...] | 0.601 |
PLPPR1 | RAP1B | ENSP00000364008 | ENSP00000250559 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function; Belongs to the small GTPase superfamily. Ras family. | 0.455 |
PLPPR1 | STX4 | ENSP00000364008 | ENSP00000317714 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.586 |
PLPPR1 | STXBP3 | ENSP00000364008 | ENSP00000359025 | Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1. | Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. | 0.625 |