node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ak9 | Cmpk1 | ENSMUSP00000134177 | ENSMUSP00000030491 | Adenylate kinase 9. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.916 |
Ak9 | Dtymk | ENSMUSP00000134177 | ENSMUSP00000027503 | Adenylate kinase 9. | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | 0.946 |
Ak9 | Dut | ENSMUSP00000134177 | ENSMUSP00000080767 | Adenylate kinase 9. | Deoxyuridine triphosphatase. | 0.930 |
Ak9 | Itpa | ENSMUSP00000134177 | ENSMUSP00000099482 | Adenylate kinase 9. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.936 |
Ak9 | Nme6 | ENSMUSP00000134177 | ENSMUSP00000035053 | Adenylate kinase 9. | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.925 |
Ak9 | Nt5c | ENSMUSP00000134177 | ENSMUSP00000021082 | Adenylate kinase 9. | 5'(3')-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | 0.667 |
Cmpk1 | Ak9 | ENSMUSP00000030491 | ENSMUSP00000134177 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Adenylate kinase 9. | 0.916 |
Cmpk1 | Dctd | ENSMUSP00000030491 | ENSMUSP00000126733 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.945 |
Cmpk1 | Dtymk | ENSMUSP00000030491 | ENSMUSP00000027503 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | 0.708 |
Cmpk1 | Dut | ENSMUSP00000030491 | ENSMUSP00000080767 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxyuridine triphosphatase. | 0.931 |
Cmpk1 | Nme6 | ENSMUSP00000030491 | ENSMUSP00000035053 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.913 |
Cmpk1 | Nt5c | ENSMUSP00000030491 | ENSMUSP00000021082 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 5'(3')-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | 0.930 |
Cmpk1 | Tk1 | ENSMUSP00000030491 | ENSMUSP00000026661 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidine kinase, cytosolic. | 0.930 |
Cmpk1 | Tk2 | ENSMUSP00000030491 | ENSMUSP00000053616 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. | 0.940 |
Cmpk1 | Tyms | ENSMUSP00000030491 | ENSMUSP00000026846 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.499 |
Dctd | Cmpk1 | ENSMUSP00000126733 | ENSMUSP00000030491 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.945 |
Dctd | Dtymk | ENSMUSP00000126733 | ENSMUSP00000027503 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | 0.969 |
Dctd | Dut | ENSMUSP00000126733 | ENSMUSP00000080767 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxyuridine triphosphatase. | 0.976 |
Dctd | Nt5c | ENSMUSP00000126733 | ENSMUSP00000021082 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 5'(3')-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | 0.939 |
Dctd | Tk1 | ENSMUSP00000126733 | ENSMUSP00000026661 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase, cytosolic. | 0.969 |