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TSO2 TSO2 RNR1-2 RNR1-2 GK3 GK3 NDPK3 NDPK3 GK-1 GK-1 GK-2 GK-2 NDPK2 NDPK2 NDK1 NDK1 NDK4 NDK4 UMK3 UMK3 UMK2 UMK2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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textmining
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protein homology
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TSO2Ribonucleoside-diphosphate reductase small chain C; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Involved in DNA damage repair and programmed cell death inhibition; Belongs to the ribonucleoside diphosphate reductase small chain family. (332 aa)    
Predicted Functional Partners:
RNR1-2
Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen. Involved in chloroplast division.
  
 0.998
GK3
Guanylate kinase 3, chloroplastic; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family.
   
 
 0.953
NDPK3
Nucleoside diphosphate kinase III, chloroplastic/mitochondrial; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Shows the highest specificity towards GDP (By similarity); Belongs to the NDK family.
  
 
 0.952
GK-1
Guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP. Required for normal development of the gametophyte and embryo, in association with GK2.
   
 
 0.952
GK-2
Guanylate kinase 2; Essential for recycling GMP and indirectly, cGMP. Required for normal development of the gametophyte and embryo, in association with GK1.
   
 
 0.952
NDPK2
Nucleoside diphosphate kinase II, chloroplastic; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. May activate MPK3 and MPK6. May be involved in the regulation of cellular redox state and hydrogen peroxide-mediated MAP kinase signaling.
  
 
 0.951
NDK1
Nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Plays a role in response to reactive oxygen species (ROS) stress.
  
 
 0.951
NDK4
Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Shows the highest specificity towards GDP (By similarity); Belongs to the NDK family.
    
 0.950
UMK3
UMP-CMP kinase 3; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Does not act on dCMP and dUMP.
   
 
 0.948
UMK2
Probable UMP-CMP kinase 2; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
     
 0.947
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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