STRINGSTRING
MBD4 MBD4 MBD4L MBD4L HHP1 HHP1 OGG1 OGG1 MBD6 MBD6 MBD8 MBD8 MBD5 MBD5 APE1L APE1L MBD7 MBD7 MBD11 MBD11 DME DME
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MBD4Methyl-CpG-binding domain-containing protein 4; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. (186 aa)    
Predicted Functional Partners:
MBD4L
Methyl-CpG-binding domain protein 4-like protein; Monofunctional DNA glycosylase targeting U:G and T:G mispairs. Excises uracil derivatives and exhibits a preference for a CpG sequence context, irrespective of the methylation status of the complementary strand. The activity follows a biphasic kinetics, with an initial burst of product accumulation followed by a slower phase. Specifically binds its reaction product. Triggers the base excision repair (BER) pathway.
      
 0.926
HHP1
Heptahelical transmembrane protein 1; May act as a negative regulator of abscisic acid (ABA)- mediated osmotic stress signaling and function in cross-talk between cold and osmotic signaling; Belongs to the ADIPOR family.
      
 0.885
OGG1
DNA-(apurinic or apyrimidinic site) lyase; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6- diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Belongs to the type-1 OGG1 family.
      
 0.826
MBD6
Methyl-CpG-binding domain-containing protein 6; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. May associate with histone deacetylase proteins (HDAC). Required for nucleolar dominance that consist in the silencing of rRNA genes inherited from one progenitor in genetic hybrids. Recruited to rRNA genes in a DRM2- dependent manner. Maintains gene silencing by interacting with RNA binding proteins (e.g. NTF2, RPS2C, HDA6 and AGO4) and by regulating DNA methylati [...]
      
 0.822
MBD8
Methyl-CpG-binding domain-containing protein 8; Probable transcriptional regulator (By similarity). May regulates developmental traits such as flowering time.
      
 0.805
MBD5
Methyl-CpG-binding domain-containing protein 5; Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing.
      
 0.802
APE1L
DNA-(apurinic or apyrimidinic site) lyase; Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting. According to a report, displays also an in vitro 3'-phosphatase activity. According to another report, has no in vitro 3'- phosphatase activity. Catalyzes the conversion of the 3'-blocking groups 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) generated by ROS1 to 3'-OH. Has a strong non-specific affinity to DNA. Redundant with APE2 and at least one functional allele is required for seed viability.
   
 
 0.797
MBD7
Methyl-CpG-binding domain-containing protein 7; Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression. Requires high mCG density for binding. Recognizes preferentially mCGs located in transposable elements. Required for active DNA demethylation. Prefers to target genomic loci [...]
      
 0.796
MBD11
Methyl-CpG-binding domain-containing protein 11; Transcriptional regulator that binds DNA independently of its methylation status. Required during plant organogenesis and development.
      
 0.796
DME
Transcriptional activator DEMETER; Transcriptional activator involved in gene imprinting. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism. Allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter. Probably acts by nicking the MEA promoter. Required for stable reproducible patterns of floral and vegetative development.
      
 0.794
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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