STRINGSTRING
msh-6 msh-6 pms-2 pms-2 msh-2 msh-2 mlh-1 mlh-1 pcn-1 pcn-1 exo-1 exo-1 crn-1 crn-1 ercc-1 ercc-1 lig-1 lig-1 pola-1 pola-1 lig-4 lig-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
msh-6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1186 aa)    
Predicted Functional Partners:
pms-2
PMS (Post Meiotic Segregation) family.
 
 0.999
msh-2
DNA_MISMATCH_REPAIR_2 domain-containing protein.
  
0.999
mlh-1
DNA_mis_repair domain-containing protein.
 
 0.999
pcn-1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.998
exo-1
EXOnuclease.
   
 0.996
crn-1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 
 0.964
ercc-1
ERCC (DNA excision repair protein) homolog.
   
 0.961
lig-1
DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 
 0.948
pola-1
DNA polymerase.
   
 
 0.943
lig-4
LIGase.
   
 0.933
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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