node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
drp1 | rad50 | Q9C0W8 | Q9UTJ8 | Protein transport protein tip20; Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex (By similarity). | DNA repair protein rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance. | 0.808 |
exo1 | mre11 | P53695 | Q09683 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | 0.998 |
exo1 | nbs1 | P53695 | O43070 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | DNA repair and telomere maintenance protein nbs1; Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure. | 0.900 |
exo1 | pku70 | P53695 | O94395 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. R [...] | 0.980 |
exo1 | rad2 | P53695 | P39750 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.902 |
exo1 | rad3 | P53695 | Q02099 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.886 |
exo1 | rad50 | P53695 | Q9UTJ8 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | DNA repair protein rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance. | 0.778 |
exo1 | rad52 | P53695 | P36592 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | DNA repair and recombination protein rad22; Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion; Belongs to the RAD52 family. | 0.971 |
exo1 | tel1 | P53695 | O74630 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length [...] | 0.869 |
exo1 | top3 | P53695 | O60126 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] | 0.962 |
mre11 | exo1 | Q09683 | P53695 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | 0.998 |
mre11 | nbs1 | Q09683 | O43070 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | DNA repair and telomere maintenance protein nbs1; Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure. | 0.999 |
mre11 | pku70 | Q09683 | O94395 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. R [...] | 0.991 |
mre11 | rad2 | Q09683 | P39750 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.983 |
mre11 | rad3 | Q09683 | Q02099 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.976 |
mre11 | rad50 | Q09683 | Q9UTJ8 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | DNA repair protein rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance. | 0.999 |
mre11 | rad52 | Q09683 | P36592 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | DNA repair and recombination protein rad22; Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion; Belongs to the RAD52 family. | 0.839 |
mre11 | tel1 | Q09683 | O74630 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length [...] | 0.986 |
mre11 | top3 | Q09683 | O60126 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] | 0.808 |
nbs1 | exo1 | O43070 | P53695 | DNA repair and telomere maintenance protein nbs1; Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure. | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | 0.900 |