TATA binding protein (Tbp) encodes a basal transcription factor required at most RNA Pol I and Pol II-transcribed genes. Traditionally thought to be recruited only to TATA box containing promoters, recent work shows that promoters with very weak TATA box consensus sequences also recruit the product of Tbp as a part of the multisubunit TFIID basal transcription factor or via the SAGA histone acetyltransferase complex.

TBP-related factor (Trf) is ubiquitiously expressed but upregulated in the central nervous system and the gonads of developing Drosophila. The majority of the product of Trf substitutes for the product of Tbp in Pol III transcription in complex with the product of Brf. The rest of the product of Trf initiates transcription of a small subset of PolII-transcribed genes regulating fly fertility and nervous system function.

Protein Dr1; Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements. Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes. Belongs to the NC2 beta/DR1 family.

TBP-associated factor 2 (Taf2) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. Together with the product of Taf1, it binds the Initiator and/or the DPE core promoter elements.

Transcription factor IIB (TfIIB) encodes a basal transcription factor that binds to the TATA box-binding protein. It is required for the initiation of transcription by RNA polymerase II.

TATA box binding protein-related factor 2 (Trf2) encodes a core promoter recognition factor that mediates gene transcription. It contributes to spiracle morphogenesis, pupal development and salivary gland cell death.

RT01008p; Transcription factor binding; RNA polymerase III regulatory region DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; RNA polymerase III preinitiation complex assembly.

Uncharacterized protein; Transcription factor binding; RNA polymerase III regulatory region DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; RNA polymerase III preinitiation complex assembly.

Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp.