node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpsf160 | Cpsf73 | FBpp0089163 | FBpp0083105 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | 0.999 |
Cpsf160 | Snm1 | FBpp0089163 | FBpp0078337 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. | LD28027p; 5'-3' exodeoxyribonuclease activity; damaged DNA binding. It is involved in the biological process described with: double-strand break repair via nonhomologous end joining; protection from non-homologous end joining at telomere; interstrand cross-link repair. | 0.881 |
Cpsf160 | Sym | FBpp0089163 | FBpp0078372 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. | Symplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. | 0.999 |
Cpsf160 | hrg | FBpp0089163 | FBpp0303281 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. | Hiiragi, isoform D; Hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb. | 0.997 |
Cpsf73 | Cpsf160 | FBpp0083105 | FBpp0089163 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. | 0.999 |
Cpsf73 | Irbp | FBpp0083105 | FBpp0081861 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | 0.531 |
Cpsf73 | Ku80 | FBpp0083105 | FBpp0080322 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.516 |
Cpsf73 | Snm1 | FBpp0083105 | FBpp0078337 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | LD28027p; 5'-3' exodeoxyribonuclease activity; damaged DNA binding. It is involved in the biological process described with: double-strand break repair via nonhomologous end joining; protection from non-homologous end joining at telomere; interstrand cross-link repair. | 0.808 |
Cpsf73 | Sym | FBpp0083105 | FBpp0078372 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | Symplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. | 0.999 |
Cpsf73 | hrg | FBpp0083105 | FBpp0303281 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | Hiiragi, isoform D; Hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb. | 0.997 |
Irbp | Cpsf73 | FBpp0081861 | FBpp0083105 | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | 0.531 |
Irbp | Ku80 | FBpp0081861 | FBpp0080322 | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.999 |
Irbp | Snm1 | FBpp0081861 | FBpp0078337 | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | LD28027p; 5'-3' exodeoxyribonuclease activity; damaged DNA binding. It is involved in the biological process described with: double-strand break repair via nonhomologous end joining; protection from non-homologous end joining at telomere; interstrand cross-link repair. | 0.911 |
Irbp | Xpac | FBpp0081861 | FBpp0070638 | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | DNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. | 0.607 |
Irbp | mus81 | FBpp0081861 | FBpp0070165 | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. | 0.722 |
Irbp | tos | FBpp0081861 | FBpp0080675 | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.920 |
Ku80 | Cpsf73 | FBpp0080322 | FBpp0083105 | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] | 0.516 |
Ku80 | Irbp | FBpp0080322 | FBpp0081861 | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | 0.999 |
Ku80 | Snm1 | FBpp0080322 | FBpp0078337 | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | LD28027p; 5'-3' exodeoxyribonuclease activity; damaged DNA binding. It is involved in the biological process described with: double-strand break repair via nonhomologous end joining; protection from non-homologous end joining at telomere; interstrand cross-link repair. | 0.905 |
Ku80 | Xpac | FBpp0080322 | FBpp0070638 | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | DNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. | 0.808 |