node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG3448 | DNAlig4 | FBpp0076204 | FBpp0073678 | RE59279p; DNA binding. It is involved in the biological process described with: positive regulation of ligase activity; response to X-ray; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation involved in DNA repair. | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | 0.928 |
CG3448 | Ercc1 | FBpp0076204 | FBpp0086578 | RE59279p; DNA binding. It is involved in the biological process described with: positive regulation of ligase activity; response to X-ray; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation involved in DNA repair. | Nucleotide excision repair protein ERCC1; Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination. | 0.572 |
CG3448 | Irbp | FBpp0076204 | FBpp0081861 | RE59279p; DNA binding. It is involved in the biological process described with: positive regulation of ligase activity; response to X-ray; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation involved in DNA repair. | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | 0.881 |
CG3448 | Ku80 | FBpp0076204 | FBpp0080322 | RE59279p; DNA binding. It is involved in the biological process described with: positive regulation of ligase activity; response to X-ray; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation involved in DNA repair. | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.584 |
DNAlig4 | CG3448 | FBpp0073678 | FBpp0076204 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | RE59279p; DNA binding. It is involved in the biological process described with: positive regulation of ligase activity; response to X-ray; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation involved in DNA repair. | 0.928 |
DNAlig4 | DNApol-theta | FBpp0073678 | FBpp0082131 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | 0.950 |
DNAlig4 | Ercc1 | FBpp0073678 | FBpp0086578 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | Nucleotide excision repair protein ERCC1; Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination. | 0.937 |
DNAlig4 | Irbp | FBpp0073678 | FBpp0081861 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | 0.986 |
DNAlig4 | Ku80 | FBpp0073678 | FBpp0080322 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.999 |
DNAlig4 | XRCC1 | FBpp0073678 | FBpp0070730 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | XRCC1 protein; Damaged DNA binding. It is involved in the biological process described with: base-excision repair; single strand break repair. | 0.975 |
DNAlig4 | okr | FBpp0073678 | FBpp0077357 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | DNA repair and recombination protein RAD54-like; Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54. | 0.936 |
DNAlig4 | spn-A | FBpp0073678 | FBpp0084955 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | DNA repair protein Rad51 homolog; Spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand. | 0.943 |
DNAlig4 | tefu | FBpp0073678 | FBpp0110174 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | Serine/threonine-protein kinase ATM; Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin- modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV. Belongs to the PI3/PI4-kinase family. AT [...] | 0.948 |
DNAlig4 | tos | FBpp0073678 | FBpp0080675 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.956 |
DNApol-theta | DNAlig4 | FBpp0082131 | FBpp0073678 | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. | 0.950 |
DNApol-theta | Ercc1 | FBpp0082131 | FBpp0086578 | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | Nucleotide excision repair protein ERCC1; Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination. | 0.593 |
DNApol-theta | Irbp | FBpp0082131 | FBpp0081861 | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | ATP-dependent DNA helicase 2 subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats. | 0.490 |
DNApol-theta | Ku80 | FBpp0082131 | FBpp0080322 | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | ATP-dependent DNA helicase II subunit 2; Ku80 (Ku80) encodes a protein that forms a Ku heterodimer with the product of Irbp, which binds to DNA double-strand break ends and is required for the non-homologous end joining pathway of DNA repair. | 0.786 |
DNApol-theta | XRCC1 | FBpp0082131 | FBpp0070730 | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | XRCC1 protein; Damaged DNA binding. It is involved in the biological process described with: base-excision repair; single strand break repair. | 0.630 |
DNApol-theta | okr | FBpp0082131 | FBpp0077357 | DNA polymerase theta; Multifunctional protein with both DNA polymerase and ATPase activities. Might have 3' to 5' exonuclease activity. Plays a role in different DNA repair pathways such as DNA strand cross-link repair and microhomology- mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks. MMEJ is an error- prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Utilizes short microhomologies present in partial [...] | DNA repair and recombination protein RAD54-like; Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54. | 0.576 |