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2449 matches
showing page 1 of 123
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organism
protein
1)
Homo sapiens
RRP8 - Ribosomal
RNA
-processing protein
8
; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]
[a.k.a. UPI00001580F8, nucleomethylin, 2ZFU]
2)
Homo sapiens
MED8 - Mediator of
RNA
polymerase II transcription subunit
8
; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal
RNA
polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with
RNA
polymerase II and the general transcription factors. May play a role as a targ [...]
[a.k.a. CCDS487.2, NP_443109.2, Mediator complex subunit 8]
3)
Homo sapiens
CNOT8 - CCR4-NOT transcription complex subunit
8
; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A)
RNA
substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...]
[a.k.a. XM_017010051.1, HGNC:9207, ENST00000520472]
4)
Homo sapiens
ZCCHC8 - Zinc finger CCHC domain-containing protein
8
; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an
RNA
exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing (Probable); Belongs to the ZCCHC8 family.
[a.k.a. NM_001350938.2, UPI000204ACBE, ZCCHC8-205]
5)
Homo sapiens
CDK8 - Cyclin-dependent kinase
8
; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal
RNA
polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with
RNA
polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...]
[a.k.a. R-HSA-170834, 1024, R-HSA-2122947]
6)
Homo sapiens
TAF8 - Transcription initiation factor TFIID subunit
8
; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by
RNA
polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). Be [...]
[a.k.a. R-HSA-6807505, TAF, XM_017010242.2]
7)
Homo sapiens
NUDT18 -
8
-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes
8
-oxo-7,
8
-dihydroguanine (
8
-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes
8
-oxo-dGDP and
8
-oxo-GDP with the same efficiencies. Hydrolyzes also
8
-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against
8
-oxo-dGTP,
8
-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and
RNA
precursor pools; Belongs to the Nudix hydrolase family.
[a.k.a. XP_011542952.1, UPI0000074169, OTTHUMG00000163774]
8)
Homo sapiens
INTS8 - Integrator complex subunit
8
; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of
RNA
polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
[a.k.a. 55656, ENST00000520853.1, ENSP00000430338]
9)
Homo sapiens
SCAF8 - SR-related and CTD-associated factor
8
; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest
RNA
polymerase II subunit (POLR2A), and subsequently binds nascent
RNA
upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...]
[a.k.a. SCAF8-204, HPA035601, NP_001273128.1]
10)
Homo sapiens
KBTBD8 - Kelch repeat and BTB domain-containing protein
8
; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect
RNA
polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
[a.k.a. ENST00000417314.2, AK096640, R-HSA-8951664]
11)
Homo sapiens
ZC3H8 - Zinc finger CCCH domain-containing protein
8
; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear
RNA
(snRNA) gene transcription by
RNA
polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
[a.k.a. NM_032494, R-HSA-6807505, NP_115883]
12)
Homo sapiens
GEMIN8 - Gem-associated protein
8
; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear
RNA
to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...]
[a.k.a. ENST00000050373, R-HSA-191859, ENSP00000381392]
13)
Mus musculus
Rrp8 - Ribosomal
RNA
-processing protein
8
; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]
[a.k.a. Rrp8-203, Q3U3A5, ENSMUST00000098148]
14)
Mus musculus
Med8 - Mediator of
RNA
polymerase II transcription subunit
8
; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal
RNA
polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with
RNA
polymerase II and the general transcription factors. May play a role as a targ [...]
[a.k.a. ENSMUSG00000006392, ENSMUSP00000019229, ENSMUST00000144577.1]
15)
Mus musculus
Cnot8 - CCR4-NOT transcription complex subunit
8
; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A)
RNA
substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...]
[a.k.a. XM_006534103.3, XP_006534167.1, AK075727]
16)
Mus musculus
Zc3h8 - Zinc finger CCCH domain-containing protein
8
; Component of the little elongation complex (LEC), a complex required to regulate small nuclear
RNA
(snRNA) gene transcription by
RNA
polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'- AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene.
[a.k.a. NP_065619.2, ENSMUSG00000027387, AAF74513.1]
17)
Mus musculus
Zcchc8 - Zinc finger CCHC domain-containing protein
8
; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an
RNA
exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing.
[a.k.a. Zinc finger, CCHC domain containing 8, XM_006530457.1, ENSMUST00000198826]
18)
Mus musculus
Cdk8 - Cyclin-dependent kinase
8
; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal
RNA
polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with
RNA
polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...]
[a.k.a. NM_153599, AAI32554.1, ENSMUST00000161652.7]
19)
Mus musculus
Taf8 - Transcription initiation factor TFIID subunit
8
; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by
RNA
polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo; Bel [...]
[a.k.a. XM_006524765.3, NM_022015.3, XP_006524830.1]
20)
Mus musculus
Nudt18 -
8
-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes
8
-oxo-7,
8
-dihydroguanine (
8
-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes
8
-oxo-dGDP and
8
-oxo-GDP with the same efficiencies. Hydrolyzes also
8
-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against
8
-oxo-dGTP,
8
-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and
RNA
precursor pools (By similarity); Belongs to the Nudix hydrolase family.
[a.k.a. BC036718, ENSMUSP00000086450, XM_006518792.1]
2449 matches
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