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crgA crgA cwsA cwsA wag31 wag31 Rv0010c Rv0010c pbpA pbpA pbpB pbpB ftsZ ftsZ ftsQ ftsQ whiA whiA Rv0057 Rv0057 Rv3843c Rv3843c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
crgAProbable conserved transmembrane protein; Involved in cell division. Plays an important role in septal peptidoglycan synthesis and cell shape morphogenesis. May facilitate the recruitment of the peptidoglycan synthesis machinery to poles and septal zones and coordinate peptidoglycan synthesis at these sites. Belongs to the CrgA family. (93 aa)    
Predicted Functional Partners:
cwsA
Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family.
   
 
 0.937
wag31
Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage.
  
  
 0.911
Rv0010c
Rv0010c, (MTCY10H4.10c), len: 141 aa. Probable conserved membrane protein. Belongs to superfamily DUF2581,conserved in the Actinomycetales. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
 
  
 0.903
pbpA
Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family.
  
 
 0.901
pbpB
Probable penicillin-binding membrane protein PbpB; Synthesis of cross-linked peptidoglycan from the lipid intermediates; Belongs to the transpeptidase family.
 
 
 0.900
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
   
 
 0.875
ftsQ
Possible cell division protein FtsQ; Essential cell division protein.
   
 
 0.843
whiA
Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation.
   
  
 0.812
Rv0057
Hypothetical protein; Rv0057, (MTCY21D4.20), len: 173 aa. Hypothetical unknown protein.
   
  
 0.804
Rv3843c
Rv3843c, (MTCY01A6.26), len: 342 aa. Probable conserved transmembrane protein, equivalent to Q9CDC6|ML0073 putative membrane protein from Mycobacterium leprae (344 aa), FASTA scores: opt: 1420, E(): 2.6e-68,(63.05% identity in 349 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
   
  
 0.804
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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