node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0102 | Rv0142 | Rv0102 | Rv0142 | Rv0102, (MTCY251.21), len: 661 aa. Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa), FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa); etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide; To M.leprae ML1998. | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.871 |
Rv0141c | Rv0142 | Rv0141c | Rv0142 | Unknown protein; Rv0141c, (MTCI5.15c), len: 136 aa. Unknown protein. | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.618 |
Rv0142 | Rv0102 | Rv0142 | Rv0102 | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Rv0102, (MTCY251.21), len: 661 aa. Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa), FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa); etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide; To M.leprae ML1998. | 0.871 |
Rv0142 | Rv0141c | Rv0142 | Rv0141c | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Unknown protein; Rv0141c, (MTCI5.15c), len: 136 aa. Unknown protein. | 0.618 |
Rv0142 | Rv3202c | Rv0142 | Rv3202c | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Possible ATP-dependent DNA helicase; Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase, showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putative ATP-dependent DNA helicase from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 mismatch repair protein MUTU (DNA helicase II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,(23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar [...] | 0.502 |
Rv0142 | end | Rv0142 | Rv0670 | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. | 0.503 |
Rv0142 | ligC | Rv0142 | Rv3731 | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | DNA ligase C; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | 0.544 |
Rv0142 | lppC | Rv0142 | Rv1911c | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Probable lipoprotein LppC; Probably involved in bacterial recognition and uptake by its host (human). | 0.519 |
Rv0142 | mymA | Rv0142 | Rv3083 | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.631 |
Rv0142 | rslA | Rv0142 | Rv0736 | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Anti-sigma factor RslA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigL. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the r [...] | 0.535 |
Rv0142 | whiB7 | Rv0142 | Rv3197A | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Probable transcriptional regulatory protein WhiB-like WhiB7; The apo- but not holo-form probably binds DNA (By similarity). Acts as a transcriptional regulator. Probably redox- responsive. Upon overproduction at least 10 other genes are up- regulated, among them are Rv1258c, Rv1988, Rv2301, Rv2416c, Rv2725c and whiB7 itself. Probably redox-responsive. The apo-form has been shown to act as a protein disulfide reductase. | 0.555 |
Rv0142 | xthA | Rv0142 | Rv0427c | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI); Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (see citation below), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. Belongs to the AP/EXOA family of DNA repair enzymes. | 0.757 |
Rv3202c | Rv0142 | Rv3202c | Rv0142 | Possible ATP-dependent DNA helicase; Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase, showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putative ATP-dependent DNA helicase from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 mismatch repair protein MUTU (DNA helicase II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,(23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar [...] | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.502 |
Rv3202c | rslA | Rv3202c | Rv0736 | Possible ATP-dependent DNA helicase; Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase, showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putative ATP-dependent DNA helicase from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 mismatch repair protein MUTU (DNA helicase II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,(23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar [...] | Anti-sigma factor RslA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigL. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the r [...] | 0.454 |
end | Rv0142 | Rv0670 | Rv0142 | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.503 |
end | xthA | Rv0670 | Rv0427c | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI); Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (see citation below), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. Belongs to the AP/EXOA family of DNA repair enzymes. | 0.951 |
ligC | Rv0142 | Rv3731 | Rv0142 | DNA ligase C; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.544 |
ligC | xthA | Rv3731 | Rv0427c | DNA ligase C; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI); Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (see citation below), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. Belongs to the AP/EXOA family of DNA repair enzymes. | 0.726 |
lppC | Rv0142 | Rv1911c | Rv0142 | Probable lipoprotein LppC; Probably involved in bacterial recognition and uptake by its host (human). | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.519 |
mymA | Rv0142 | Rv3083 | Rv0142 | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | 0.631 |