node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0207c | Rv0209 | Rv0207c | Rv0209 | Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein. | 0.730 |
Rv0207c | Rv0210 | Rv0207c | Rv0210 | Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | 0.775 |
Rv0207c | mmpL3 | Rv0207c | Rv0206c | Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Possible conserved transmembrane transport protein MmpL3; Transports trehalose monomycolate (TMM) across the inner membrane. Could also be part of a heme-iron acquisition system. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. | 0.874 |
Rv0207c | trmB | Rv0207c | Rv0208c | Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Hypothetical methlytransferase (methylase); Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.989 |
Rv0209 | Rv0207c | Rv0209 | Rv0207c | Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein. | Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.730 |
Rv0209 | Rv0210 | Rv0209 | Rv0210 | Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein. | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | 0.976 |
Rv0209 | mmpL3 | Rv0209 | Rv0206c | Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein. | Possible conserved transmembrane transport protein MmpL3; Transports trehalose monomycolate (TMM) across the inner membrane. Could also be part of a heme-iron acquisition system. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. | 0.487 |
Rv0209 | trmB | Rv0209 | Rv0208c | Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein. | Hypothetical methlytransferase (methylase); Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.776 |
Rv0210 | Rv0207c | Rv0210 | Rv0207c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.775 |
Rv0210 | Rv0209 | Rv0210 | Rv0209 | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein. | 0.976 |
Rv0210 | Rv1978 | Rv0210 | Rv1978 | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Conserved protein; Rv1978, (MTV051.16), len: 282 aa. Conserved protein,similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151,E(): 0.0072, (30.6% identity in 121 aa overlap). | 0.732 |
Rv0210 | Rv2474c | Rv0210 | Rv2474c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Rv2474c, (MTV008.30c), len: 217 aa. Hypothetical protein. Shows weak similarity with Q9L246|SC6D10.18c hypothetical 24.9 KDA protein from Streptomyces coelicolor (238 aa), FASTA scores: opt: 111, E(): 5.6, (30% identity in 233 aa overlap), blastp scores: Score= 135, E= 3.5e-07,P= 3.5e-07, Identities= 55/182 (30%). | 0.750 |
Rv0210 | Rv2686c | Rv0210 | Rv2686c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter; Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane. | 0.734 |
Rv0210 | Rv2687c | Rv0210 | Rv2687c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter; Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane. | 0.739 |
Rv0210 | mmpL3 | Rv0210 | Rv0206c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Possible conserved transmembrane transport protein MmpL3; Transports trehalose monomycolate (TMM) across the inner membrane. Could also be part of a heme-iron acquisition system. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. | 0.722 |
Rv0210 | papA3 | Rv0210 | Rv1182 | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Probable conserved polyketide synthase associated protein PapA3; Involved in the biosynthesis of polyacyltrehalose (PAT) which could have a role in anchoring the bacterial capsule. In vitro catalyzes the sequential transfer of two palmitoyl groups onto a single glucose residue of trehalose generating the diacylated product 2,3- diacyltrehalose (trehalose dipalmitate). Although palmitoyl-CoA (PCoA) seems to be the physiological acyl donor, PapA3 can also use docosanoyl (22-carbon saturated fatty acid) coenzyme A as acyl donor. | 0.716 |
Rv0210 | rsdA | Rv0210 | Rv3413c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Unknown alanine and proline rich protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigD. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P), while cytoplasmic proteases finish deg [...] | 0.746 |
Rv0210 | trmB | Rv0210 | Rv0208c | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | Hypothetical methlytransferase (methylase); Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.801 |
Rv1978 | Rv0210 | Rv1978 | Rv0210 | Conserved protein; Rv1978, (MTV051.16), len: 282 aa. Conserved protein,similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151,E(): 0.0072, (30.6% identity in 121 aa overlap). | Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381. | 0.732 |
Rv1978 | Rv2686c | Rv1978 | Rv2686c | Conserved protein; Rv1978, (MTV051.16), len: 282 aa. Conserved protein,similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151,E(): 0.0072, (30.6% identity in 121 aa overlap). | Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter; Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane. | 0.772 |