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lpqM lpqM lpqL lpqL lpqW lpqW lppL lppL Rv0882 Rv0882 Rv3212 Rv3212 Rv2980 Rv2980 lpqB lpqB Rv2091c Rv2091c Rv0556 Rv0556 Rv2049c Rv2049c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Coexpression
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[Homology]
Score
lpqMRv0419, (MTCY22G10.16), len: 498 aa. Possible lpqM,lipoprotein peptidase; has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. (498 aa)    
Predicted Functional Partners:
lpqL
Probable lipoprotein aminopeptidase LpqL; An aminopeptidase; acts on free N-terminal amino groups with a very strong preference for Leu in the first position. Belongs to the peptidase M28 family. M28A subfamily.
 
  
 0.883
lpqW
Probable conserved lipoprotein LpqW; May directly or indirectly regulate the accessibility of the key branch point intermediate, monoacyl phosphatidylinositol tetramannoside (AcPIM4), to the elongating alpha-1,6 mannosyltransferases which could regulate the lipoarabinomannans (LAMs) biosynthesis; Belongs to the bacterial solute-binding protein 5 family.
  
  
 0.791
lppL
Rv2138, (MTCY270.30c), len: 358 aa. Probable lppL,conserved lipoprotein, with appropriately placed lipoprotein signature (PS00013) strongly similar to hypothetical Mycobacterium leprae protein, Q49806. FASTA best: Q49806 B2126_F3_142. (298 aa) opt: 1495, E(): 0; (75.3% identity in 300 aa overlap).
  
  
 0.789
Rv0882
Rv0882, (MTCY31.10), len: 94 aa. Probable transmembrane protein.
  
     0.760
Rv3212
Rv3212, (MTCY07D11.14c), len: 407 aa. Conserved ala-, val-rich protein, equivalent to Q9CCH4|ML0810 putative membrane protein from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 trans-acting transcriptional protein from Herpes simplex virus (type 1 / strain 17) (775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). Predi [...]
 
    0.758
Rv2980
Rv2980, (MTCY349.07c), len: 181 aa. Possible conserved secreted protein, equivalent to Q9CBS1 possible secreted protein from Mycobacterium leprae (191 aa), FASTA scores: opt: 794, E(): 2.3e-40, (67.25% identity in 177 aa overlap). Also some weak similarity with other hypothetical proteins or secreted proteins e.g. C-terminus of Q98F98|MLL3872 MLL3872 protein from Rhizobium loti (Mesorhizobium loti) (575 aa), FASTA scores: opt: 148, E(): 0.16, (28.35% identity in 194 aa overlap); Q9L0W9|SCH22A.13C putative secreted protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 114,E( [...]
  
     0.735
lpqB
Probable conserved lipoprotein LpqB; May modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division (By similarity). Partially restores antibiotic resistance to M.smegmatis in which this gene has been disrupted.
  
  
 0.724
Rv2091c
Probable membrane protein; Rv2091c, (MTCY49.31c), len: 244 aa. Probable membrane protein; contains potential transmembrane region. Repetitive ORF. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
    0.709
Rv0556
Rv0556, (MTCY25D10.35), len: 171 aa. Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004).
  
    0.704
Rv2049c
Rv2049c, (MTV018.36c), len: 74 aa. Conserved hypothetical protein.
  
    0.704
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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