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psd psd pssA pssA plcD plcD plcC plcC plcB plcB plcA plcA Rv0435c Rv0435c Rv1279 Rv1279 moeA2 moeA2 pgsA3 pgsA3 pgsA2 pgsA2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
psdPossible phosphatidylserine decarboxylase Psd (PS decarboxylase); Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (231 aa)    
Predicted Functional Partners:
pssA
Rv0436c, (MTCY22G10.33c), len: 286 aa. Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (see citation below), integral membrane protein, equivalent to AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in 285 aa overlap). Also highly similar to others e.g. NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine o-phosphatidyltransferase from Bacillus subtilis (177 aa), FASTA scores: opt: 277, E(): 9.9e-1 [...]
 
 
 0.999
plcD
Rv1755c, (MT1799, MTCY28.21c), len: 280 aa. Probable plcD, phospholipase C 4 (fragment) (see citations below),highly similar to C-terminus of other phospholipases e.g. CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 from Mycobacterium tuberculosis (512 aa), FASTA score: (71.1% identity in 284 aa overlap); etc. Note that this ORF has been interrupted by insertion of IS6110 element. Belongs to the bacterial phospholipase C family.
     
  0.900
plcC
Rv2349c, (MT2414, MTCY98.18c), len: 508 aa. Probable plcC, phospolipase C 3 (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C precursor from Pseudomonas aeruginosa (692 aa), FASTA scores: opt: 1013, E(): 9.3e-54, (38.85% identity in 525 aa overlap); P06200|PHLC_PSEAE hemolytic phospholipase C precursor from Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 630, E(): 1.5e-30, (35.15% identity in 535 aa overlap); Q9S816|T12J13.18|T21P5.4 putative phospholipase from Arabidopsis thaliana (Mouse-ear cr [...]
     
  0.900
plcB
Membrane-associated phospholipase C 2 PlcB; Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity.
   
 
  0.900
plcA
Membrane-associated phospholipase C 1 PlcA (MTP40 antigen); Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity; Belongs to the bacterial phospholipase C family.
   
 
  0.900
Rv0435c
Putative conserved ATPase; Rv0435c, (MTCY22G10.32c), len: 728 aa. Putative conserved ATPase, similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, E(): 0,(34.5% identity in 693 aa overlap); NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature.
  
  
 0.888
Rv1279
Rv1279, (MTCY50.03c), len: 528 aa. Probable dehydrogenase, FAD flavoprotein GMC oxidoreductase, similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa), FASTA scores, opt: 1047,E(): 0, (37.7% identity in 541 aa overlap). Similar to Rv0697 putative Mycobacterium tuberculosis GMC oxidoreductase. Contains PS00623 GMC oxidoreductases signature 1, and PS00624 GMC oxidoreductases signature 2. Belongs to the GMC oxidoreductases family.
   
 
 0.808
moeA2
Probable molybdopterin biosynthesis protein MoeA2; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
  
    0.807
pgsA3
Probable phosphatidylglycerophosphate synthase; Probably catalyzes the synthesis of phosphatidylglycerophosphate by transferring a phosphatidyl group from CDP-diacylglycerol to glycerol 3-phosphate. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
 
 0.712
pgsA2
Putative cardiolipin synthase; May catalyze the biosynthesis of cardiolipin from phosphatidylglycerol (PG) and CDP-diacylglycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
   
 
 0.711
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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