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PE_PGRS6 PE_PGRS6 Rv1526c Rv1526c Rv1924c Rv1924c Rv1937 Rv1937 Rv1875 Rv1875 Rv1728c Rv1728c pepE pepE Rv2971 Rv2971 pdtaR pdtaR cmr cmr nuoF nuoF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PE_PGRS6PE-PGRS family protein PE_PGRS6; Rv0532, (MTCY25D10.11), len: 594 aa. PE_PGRS6,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). (594 aa)    
Predicted Functional Partners:
Rv1526c
Rv1526c, (MTCY19G5.02), len: 426 aa. Probable glycosyltransferase, highly similar to G467196 Protein L518_C2_147 from Mycobacterium leprae (421 aa), FASTA scores, opt: 1497, E(): 0, (55.0% identity in 424 aa overlap); similar to G452504 rhamnosyltransferase (24.7% identity in 433 aa overlap); and P96565|U84350 glycosyltransferase GTFE from Amycolatopsis orientalis (408 aa), E(): 3.4e-24, (28.4% identity in 429 aa overlap), also high similarity to Rv1524|MTCY19G5.04c (58.7 % identity in 416 aa overlap).
      
 0.801
Rv1924c
Unknown protein; Rv1924c, (MTCY09F9.40), len: 126 aa. Unknown protein.
      
 0.801
Rv1937
Possible oxygenase; Rv1937, (MTCY09F9.27c), len: 839 aa. Possible oxygenase, similar in N-terminus to N-terminal part (approx. 350 aa) of dioxygenases (including ring-hydroxylating dioxygenase electron transfer components) and monooxygenases, e.g. AAC34815.1|AF071556 anthranilate dioxygenase reductase from Acinetobacter sp. (343 aa); AAK52291.1|AY026914|AntC putative anthranilate dioxygenase reductase from Pseudomonas putida (340 aa); AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase / ferredoxin reductase from Pseudomonas putida (336 aa); P23101|XYLZ_PSEPU toluate 1,2-dioxygenase el [...]
     
 0.801
Rv1875
Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09,(38.7% identity in 137 aa overlap).
     
 0.656
Rv1728c
Conserved hypothetical protein; Rv1728c, (MTCY04C12.13c), len: 256 aa. Conserved hypothetical protein, some similarity to O07246|Rv0320|MTCY63.25 possible exported protein from Mycobacterium tuberculosis (220 aa), FASTA scores: E(): 1.3e-31, (42.3% identity in 220 aa overlap). C-terminal region similar to Q9ZX60|AF068845|AF068845_17 segment of gp17 of Mycobacteriophage TM4 (1229 aa), FASTA scores: opt: 385, E(): 4.3e-17, (44.6% identity in 139 aa overlap).
      
 0.654
pepE
Dipeptidase PepE; Rv2089c, (MTCY49.29c), len: 375 aa. PepE,dipeptidase, similar to many; contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tuberculosis peptidases Rv2861c,Rv0734, Rv2535c. Phosphorylated in vitro by PknJ|Rv2088 (See Jang et al., 2010); Belongs to the peptidase M24B family.
     
 0.545
Rv2971
Rv2971, (MTCY349.16c), len: 282 aa. Probable oxidoreductase, possibly aldo/keto reductase, equivalent to O69462 putative oxidoreductase from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495, E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C oxidoreductase from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49,(51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C putative oxidoreductase from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49, (49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI [...]
      
 0.528
pdtaR
Probable two-component system transcriptional regulator; Member of the two-component regulatory system PdtaR/PdtaS.
      
 0.519
cmr
Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro.
      
 0.517
nuoF
Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 51 kDa subunit family.
      
 0.513
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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