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menH menH menD menD menA menA menC menC mgtA mgtA entC entC menB menB desA3 desA3 Rv0560c Rv0560c Rv0556 Rv0556 menE menE
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
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menHDemethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2); Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. (234 aa)    
Predicted Functional Partners:
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
  
  
 0.982
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase); Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Can use a variety of allylic isoprenyl diphosphates as substrates but has a requirement for at least three isoprene units; Belongs to the MenA family. Type 1 subfamily.
  
 
 0.961
menC
Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE); Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB); Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
  
  
 0.943
mgtA
Mannosyltransferase MgtA; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)- glycerol(ManGlcAGroAc2).
     
 0.866
entC
Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis); Catalyzes the conversion of chorismate to isochorismate.
     
 0.837
menB
Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase); Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
  
  
 0.768
desA3
Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA.
   
  
 0.664
Rv0560c
Rv0560c, (MTCY25D10.39c), len: 241 aa. Possible benzoquinone methyltransferase (see citation below),similar to other hypothetical proteins and methyltransferases e.g. Q54300 methyltransferase (211 aa),FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity in 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c, etc from Mycobacterium tuberculosis. Rv0560c can be induced by salicylate and para-amino-salicylate (pas).
   
  
 0.660
Rv0556
Rv0556, (MTCY25D10.35), len: 171 aa. Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004).
  
    0.643
menE
Probable 2-succinylbenzoate--CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). May be involved in the biosynthesis of menaquinone (By similarity).
 
  
 0.624
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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