node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
vapB34 | vapB4 | Rv1740 | Rv0596c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | 0.628 |
vapB34 | vapC20 | Rv1740 | Rv2549c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | 0.513 |
vapB34 | vapC26 | Rv1740 | Rv0582 | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC26. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB26.; Belongs to the PINc/VapC protein family. | 0.514 |
vapB34 | vapC30 | Rv1740 | Rv0624 | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.; Belongs to the PINc/VapC protein family. | 0.943 |
vapB34 | vapC4 | Rv1740 | Rv0595c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.803 |
vapB4 | vapB34 | Rv0596c | Rv1740 | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | 0.628 |
vapB4 | vapC26 | Rv0596c | Rv0582 | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible toxin VapC26. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB26.; Belongs to the PINc/VapC protein family. | 0.438 |
vapB4 | vapC30 | Rv0596c | Rv0624 | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.; Belongs to the PINc/VapC protein family. | 0.428 |
vapB4 | vapC4 | Rv0596c | Rv0595c | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.985 |
vapB5 | vapC25 | Rv0626 | Rv0277c | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | Possible toxin VapC25. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB25.; Belongs to the PINc/VapC protein family. | 0.457 |
vapB5 | vapC30 | Rv0626 | Rv0624 | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.; Belongs to the PINc/VapC protein family. | 0.669 |
vapB5 | vapC31 | Rv0626 | Rv0749 | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | Possible toxin VapC31. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity). | 0.520 |
vapB5 | vapC33 | Rv0626 | Rv1242 | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | Possible toxin VapC33. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB33.; Belongs to the PINc/VapC protein family. | 0.488 |
vapB5 | vapC4 | Rv0626 | Rv0595c | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.977 |
vapC20 | vapB34 | Rv2549c | Rv1740 | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | 0.513 |
vapC20 | vapC25 | Rv2549c | Rv0277c | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | Possible toxin VapC25. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB25.; Belongs to the PINc/VapC protein family. | 0.733 |
vapC20 | vapC26 | Rv2549c | Rv0582 | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | Possible toxin VapC26. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB26.; Belongs to the PINc/VapC protein family. | 0.910 |
vapC20 | vapC30 | Rv2549c | Rv0624 | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.; Belongs to the PINc/VapC protein family. | 0.505 |
vapC20 | vapC31 | Rv2549c | Rv0749 | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | Possible toxin VapC31. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity). | 0.519 |
vapC20 | vapC32 | Rv2549c | Rv1114 | Possible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin loop (SRL, E.coli 23S rRNA numbering). The SRL sequence is highly conserved and is implicated in GTP hydrolysis by EF-Tu and EF-G. Acts on purified ribosomes but not on isolated RNA in E.coli, nor on a shortened artificial substrate. Upon expression in E.coli inhibits cell growth, colony formation and translation. Its toxic effect is neutralized by coexpression, or subsequent expression (tested [...] | Possible toxin VapC32. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB32.; Belongs to the PINc/VapC protein family. | 0.703 |